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• W2024672561 abstract "Macrocyclic polyketides exhibit an impressive range of medically useful activities, and there is great interest in manipulating the genes that govern their synthesis. The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, has been modified by repositioning of a chain-terminating cyclase domain to the carboxyl-terminus of DEBS1, the multienzyme that catalyzes the first two rounds of polyketide chain extension. The resulting mutant markedly accelerates formation of the predicted triketide lactone, compared to a control in which the repositioned domain is inactive. Repositioning of the cyclase should be generally useful for redirecting polyketide synthesis to obtain polyketides of specified chain lengths." @default.
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• W2024672561 date "1995-06-09" @default.
• W2024672561 modified "2023-09-27" @default.
• W2024672561 title "Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage" @default.
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• W2024672561 doi "https://doi.org/10.1126/science.7770773" @default.
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