Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024672968> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2024672968 abstract "One desirable endpoint of general anesthesia is the state of unconsciousness, also known as hypnosis. Defining the hypnotic state in animals is less straightforward than it is in human patients. A widely used behavioral surrogate for hypnosis in rodents is the loss of righting reflex (LORR), or the point at which the animal no longer responds to their innate instinct to avoid the vulnerability of dorsal recumbency. We have developed a system to assess LORR in 24 mice simultaneously while carefully controlling for potential confounds, including temperature fluctuations and varying gas flows. These chambers permit reliable assessment of anesthetic sensitivity as measured by latency to return of the righting reflex (RORR) following a fixed anesthetic exposure. Alternatively, using stepwise increases (or decreases) in anesthetic concentration, the chambers also enable determination of a population's sensitivity to induction (or emergence) as measured by EC50 and Hill slope. Finally, the controlled environmental chambers described here can be adapted for a variety of alternative uses, including inhaled delivery of other drugs, toxicology studies, and simultaneous real-time monitoring of vital signs." @default.
- W2024672968 created "2016-06-24" @default.
- W2024672968 creator A5007293568 @default.
- W2024672968 creator A5042974972 @default.
- W2024672968 creator A5059303690 @default.
- W2024672968 date "2013-10-16" @default.
- W2024672968 modified "2023-10-18" @default.
- W2024672968 title "Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention" @default.
- W2024672968 cites W1489826564 @default.
- W2024672968 cites W1603709892 @default.
- W2024672968 cites W1606968589 @default.
- W2024672968 cites W1965533477 @default.
- W2024672968 cites W1971248719 @default.
- W2024672968 cites W1978348024 @default.
- W2024672968 cites W1979104793 @default.
- W2024672968 cites W1986260306 @default.
- W2024672968 cites W1986405188 @default.
- W2024672968 cites W1992126265 @default.
- W2024672968 cites W1993746910 @default.
- W2024672968 cites W1994808325 @default.
- W2024672968 cites W1997311667 @default.
- W2024672968 cites W1997463427 @default.
- W2024672968 cites W2000306331 @default.
- W2024672968 cites W2011581625 @default.
- W2024672968 cites W2033123925 @default.
- W2024672968 cites W2042113260 @default.
- W2024672968 cites W2050752240 @default.
- W2024672968 cites W2051384070 @default.
- W2024672968 cites W2051941528 @default.
- W2024672968 cites W2064331062 @default.
- W2024672968 cites W2074671627 @default.
- W2024672968 cites W2085138535 @default.
- W2024672968 cites W2087748297 @default.
- W2024672968 cites W2088319791 @default.
- W2024672968 cites W2088715256 @default.
- W2024672968 cites W2093126183 @default.
- W2024672968 cites W2122321125 @default.
- W2024672968 cites W2130225921 @default.
- W2024672968 cites W2135826809 @default.
- W2024672968 cites W2160543798 @default.
- W2024672968 cites W2411081097 @default.
- W2024672968 cites W576610066 @default.
- W2024672968 cites W2557851356 @default.
- W2024672968 doi "https://doi.org/10.3791/51079" @default.
- W2024672968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3940706" @default.
- W2024672968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24192721" @default.
- W2024672968 hasPublicationYear "2013" @default.
- W2024672968 type Work @default.
- W2024672968 sameAs 2024672968 @default.
- W2024672968 citedByCount "10" @default.
- W2024672968 countsByYear W20246729682014 @default.
- W2024672968 countsByYear W20246729682015 @default.
- W2024672968 countsByYear W20246729682017 @default.
- W2024672968 countsByYear W20246729682018 @default.
- W2024672968 countsByYear W20246729682021 @default.
- W2024672968 countsByYear W20246729682022 @default.
- W2024672968 crossrefType "journal-article" @default.
- W2024672968 hasAuthorship W2024672968A5007293568 @default.
- W2024672968 hasAuthorship W2024672968A5042974972 @default.
- W2024672968 hasAuthorship W2024672968A5059303690 @default.
- W2024672968 hasBestOaLocation W20246729682 @default.
- W2024672968 hasConcept C131783052 @default.
- W2024672968 hasConcept C2776470351 @default.
- W2024672968 hasConcept C2778162923 @default.
- W2024672968 hasConcept C2908647359 @default.
- W2024672968 hasConcept C42219234 @default.
- W2024672968 hasConcept C71924100 @default.
- W2024672968 hasConcept C83974742 @default.
- W2024672968 hasConcept C99454951 @default.
- W2024672968 hasConceptScore W2024672968C131783052 @default.
- W2024672968 hasConceptScore W2024672968C2776470351 @default.
- W2024672968 hasConceptScore W2024672968C2778162923 @default.
- W2024672968 hasConceptScore W2024672968C2908647359 @default.
- W2024672968 hasConceptScore W2024672968C42219234 @default.
- W2024672968 hasConceptScore W2024672968C71924100 @default.
- W2024672968 hasConceptScore W2024672968C83974742 @default.
- W2024672968 hasConceptScore W2024672968C99454951 @default.
- W2024672968 hasIssue "80" @default.
- W2024672968 hasLocation W20246729681 @default.
- W2024672968 hasLocation W20246729682 @default.
- W2024672968 hasLocation W20246729683 @default.
- W2024672968 hasLocation W20246729684 @default.
- W2024672968 hasOpenAccess W2024672968 @default.
- W2024672968 hasPrimaryLocation W20246729681 @default.
- W2024672968 hasRelatedWork W2012680029 @default.
- W2024672968 hasRelatedWork W2031237402 @default.
- W2024672968 hasRelatedWork W2358452761 @default.
- W2024672968 hasRelatedWork W2378127585 @default.
- W2024672968 hasRelatedWork W2380674051 @default.
- W2024672968 hasRelatedWork W2944203481 @default.
- W2024672968 hasRelatedWork W3092790733 @default.
- W2024672968 hasRelatedWork W3097397491 @default.
- W2024672968 hasRelatedWork W3117223433 @default.
- W2024672968 hasRelatedWork W2414510344 @default.
- W2024672968 isParatext "false" @default.
- W2024672968 isRetracted "false" @default.
- W2024672968 magId "2024672968" @default.
- W2024672968 workType "article" @default.