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- W2024674786 abstract "A new biodegradable amphiphilic block copolymer, poly(ethylene glycol)-b-poly(l-lactide-co-9-phenyl-2,4,8,10-tetraoxaspiro[5,5]undecan-3-one) [PEG-b-P(LA-co-PTO)], was successfully prepared by ring-opening polymerization (ROP) of l-lactide (LA) and functionalized carbonate monomer 9-phenyl-2,4,8,10-tetraozaspiro[5,5]undecan-3-one (PTO) in the presence of monohydroxyl poly(ethylene glycol) as macroinitiator using Sn(Oct)2 as catalyst. NMR, FT-IR, and GPC studies confirmed the copolymer structure. It could self-assemble into micelles in aqueous solution with critical micelle concentration (CMC) in the magnitude of mg/L, which changed with the composition of the copolymer. After catalytic hydrogenation, copolymers with active hydroxyl groups were obtained. Adhesion and proliferation of Vero cells on the copolymer films showed that the synthesized copolymers were good biocompatible materials. In vitro degradation of the copolymer before and after deprotection was investigated in the presence of proteinase K. The free hydroxyl groups on the copolymers were capable of further modification with biotin. This new amphiphilic block copolymer has great potential for both drug encapsulation and conjugate because of its low CMC and the presence of active hydroxyl groups." @default.
- W2024674786 created "2016-06-24" @default.
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- W2024674786 date "2008-01-22" @default.
- W2024674786 modified "2023-10-18" @default.
- W2024674786 title "Biodegradable Amphiphilic Block Copolymers Bearing Protected Hydroxyl Groups: Synthesis and Characterization" @default.
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- W2024674786 doi "https://doi.org/10.1021/bm701092j" @default.
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