Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024674911> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2024674911 endingPage "90" @default.
- W2024674911 startingPage "85" @default.
- W2024674911 abstract "These studies were conducted to identify the P450 isozymes participating in the metabolism of thiram (tetramethylthiuram disulfide) and its two metabolites DMDC (dimethyldithiocarbamate) and CS2 (carbon disulfide), and to establish the relationship between the P450-mediated metabolism of these compounds and their possible hepatotoxic effects. These compounds were individually administered i.p. to normal rats at two equimolar doses (0.1 and 0.5 mmol/kg).The animals were sacrificed at 3 h after treatment to identify the inhibited isozymes, and at 24 h to determine the hepatic damage. The results indicated that only the higher dose of thiram inhibited the activities of CYP1A1 and 2B1 significantly at 3 h after treatment whereas CYP2E1 was depressed by both doses and CYP3A2 remained unaffected by either dose. At 24 h after treatment, higher dose of thiram significantly depressed only the CYP1A1 and 2E1 activities. Both CYP1A1 and 2E1 were inhibited by higher dose of DMDC, but there was no significant inhibition of CYP2B1 or 3A2 by DMDC at 3 h following treatment. Unlike thiram, DMDC did not affect the activity of any of the CYP isozymes at 24 h after treatment. At 3 h post-treatment, although the higher dose of CS2 significantly inhibited CYP1A1, 2B1, 2E1, and 3A2, the lower dose decreased the activities of only CYP1A1, 2B1, and 2E1. On the other hand, CS2 increased the activities of CYP1A1, 2B1, and 2E1 at 24 h following treatment with no effect on CYP3A2. It is further observed from the results that only thiram at higher dose caused liver damage as measured by a significant increase in the activities of SDH and ALT. The results suggest that CYP1A1, 2B1, and 2E1 appear to be mostly involved in the metabolism of these compounds, and among them only thiram is hepatotoxic." @default.
- W2024674911 created "2016-06-24" @default.
- W2024674911 creator A5002977456 @default.
- W2024674911 creator A5013094727 @default.
- W2024674911 creator A5015376796 @default.
- W2024674911 creator A5029065674 @default.
- W2024674911 creator A5055195809 @default.
- W2024674911 date "2002-10-01" @default.
- W2024674911 modified "2023-09-28" @default.
- W2024674911 title "Toxicologic implications of the metabolism of thiram, dimethyldithiocarbamate and carbon disulfide mediated by hepatic cytochrome P450 isozymes in rats" @default.
- W2024674911 cites W1575831698 @default.
- W2024674911 cites W1974982210 @default.
- W2024674911 cites W1987742842 @default.
- W2024674911 cites W1988092416 @default.
- W2024674911 cites W1998062783 @default.
- W2024674911 cites W2017729229 @default.
- W2024674911 cites W2020581272 @default.
- W2024674911 cites W2025098860 @default.
- W2024674911 cites W2036326529 @default.
- W2024674911 cites W2049424582 @default.
- W2024674911 cites W2054022216 @default.
- W2024674911 cites W2057406230 @default.
- W2024674911 cites W2059498094 @default.
- W2024674911 cites W2076779820 @default.
- W2024674911 cites W2105342603 @default.
- W2024674911 cites W2138145189 @default.
- W2024674911 cites W4232524703 @default.
- W2024674911 cites W4232534952 @default.
- W2024674911 doi "https://doi.org/10.1016/s0048-3575(02)00149-9" @default.
- W2024674911 hasPublicationYear "2002" @default.
- W2024674911 type Work @default.
- W2024674911 sameAs 2024674911 @default.
- W2024674911 citedByCount "15" @default.
- W2024674911 countsByYear W20246749112012 @default.
- W2024674911 countsByYear W20246749112016 @default.
- W2024674911 countsByYear W20246749112017 @default.
- W2024674911 countsByYear W20246749112019 @default.
- W2024674911 countsByYear W20246749112021 @default.
- W2024674911 countsByYear W20246749112022 @default.
- W2024674911 countsByYear W20246749112023 @default.
- W2024674911 crossrefType "journal-article" @default.
- W2024674911 hasAuthorship W2024674911A5002977456 @default.
- W2024674911 hasAuthorship W2024674911A5013094727 @default.
- W2024674911 hasAuthorship W2024674911A5015376796 @default.
- W2024674911 hasAuthorship W2024674911A5029065674 @default.
- W2024674911 hasAuthorship W2024674911A5055195809 @default.
- W2024674911 hasConcept C119795356 @default.
- W2024674911 hasConcept C140027455 @default.
- W2024674911 hasConcept C178790620 @default.
- W2024674911 hasConcept C181199279 @default.
- W2024674911 hasConcept C185592680 @default.
- W2024674911 hasConcept C2777855856 @default.
- W2024674911 hasConcept C2779607818 @default.
- W2024674911 hasConcept C526171541 @default.
- W2024674911 hasConcept C55493867 @default.
- W2024674911 hasConcept C59822182 @default.
- W2024674911 hasConcept C62231903 @default.
- W2024674911 hasConcept C71924100 @default.
- W2024674911 hasConcept C74600772 @default.
- W2024674911 hasConcept C86803240 @default.
- W2024674911 hasConcept C98274493 @default.
- W2024674911 hasConceptScore W2024674911C119795356 @default.
- W2024674911 hasConceptScore W2024674911C140027455 @default.
- W2024674911 hasConceptScore W2024674911C178790620 @default.
- W2024674911 hasConceptScore W2024674911C181199279 @default.
- W2024674911 hasConceptScore W2024674911C185592680 @default.
- W2024674911 hasConceptScore W2024674911C2777855856 @default.
- W2024674911 hasConceptScore W2024674911C2779607818 @default.
- W2024674911 hasConceptScore W2024674911C526171541 @default.
- W2024674911 hasConceptScore W2024674911C55493867 @default.
- W2024674911 hasConceptScore W2024674911C59822182 @default.
- W2024674911 hasConceptScore W2024674911C62231903 @default.
- W2024674911 hasConceptScore W2024674911C71924100 @default.
- W2024674911 hasConceptScore W2024674911C74600772 @default.
- W2024674911 hasConceptScore W2024674911C86803240 @default.
- W2024674911 hasConceptScore W2024674911C98274493 @default.
- W2024674911 hasIssue "2" @default.
- W2024674911 hasLocation W20246749111 @default.
- W2024674911 hasOpenAccess W2024674911 @default.
- W2024674911 hasPrimaryLocation W20246749111 @default.
- W2024674911 hasRelatedWork W129420355 @default.
- W2024674911 hasRelatedWork W1978392142 @default.
- W2024674911 hasRelatedWork W1992574560 @default.
- W2024674911 hasRelatedWork W2009252359 @default.
- W2024674911 hasRelatedWork W2024674911 @default.
- W2024674911 hasRelatedWork W2027130771 @default.
- W2024674911 hasRelatedWork W2064928562 @default.
- W2024674911 hasRelatedWork W2079315219 @default.
- W2024674911 hasRelatedWork W2408203271 @default.
- W2024674911 hasRelatedWork W2419414102 @default.
- W2024674911 hasVolume "74" @default.
- W2024674911 isParatext "false" @default.
- W2024674911 isRetracted "false" @default.
- W2024674911 magId "2024674911" @default.
- W2024674911 workType "article" @default.