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• W2024674930 abstract "Stress relief: Orexin neuropeptides regulate arousal and stress processing through orexin receptor type 1 (OXR-1) and 2 (OXR-2) signaling. A selective OXR-1 antagonist, represented by a phenylglycine-amide substituted tetrahydropapaverine derivative (ACT-335827), is described that is orally available, penetrates the brain, and decreases fear, compulsive behaviors and autonomic stress reactions in rats." @default.
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• W2024674930 date "2013-04-15" @default.
• W2024674930 modified "2023-10-17" @default.
• W2024674930 title "Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist" @default.
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• W2024674930 doi "https://doi.org/10.1002/cmdc.201300003" @default.
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