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- W2024676188 abstract "The budding yeast Saccharomyces cerevisiae, a powerful model system for the study of basic eukaryotic cell biology, has been used increasingly as a screening tool for the identification of bioactive small molecules. We have developed a novel yeast toxicity screen that is easily automated and compatible with high-throughput screening robotics. The new screen is quantitative and allows inhibitory potencies to be determined, since the diffusion of the sample provides a concentration gradient and a corresponding toxicity halo. The efficacy of this new screen was illustrated by testing materials including 3104 compounds from the NCI libraries, 167 marine sponge crude extracts, and 149 crude marine-derived fungal extracts. There were 46 active compounds among the NCI set. One very active extract was selected for bioactivity-guided fractionation, resulting in the identification of crambescidin 800 as a potent antifungal agent." @default.
- W2024676188 created "2016-06-24" @default.
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- W2024676188 date "2007-02-10" @default.
- W2024676188 modified "2023-10-17" @default.
- W2024676188 title "Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay" @default.
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- W2024676188 doi "https://doi.org/10.1021/np060555t" @default.
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