FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024677687> ?p ?o ?g. }

• W2024677687 endingPage "519" @default.
• W2024677687 startingPage "505" @default.
• W2024677687 abstract "The elongation phase of RNA transcription represents a major target for the regulation of gene expression. Two general classes of models have been proposed to define the dynamic properties of transcription complexes in the elongation phase. Stable heterogeneity models posit that the ensemble of active elongation-competent complexes consists of multiple distinct and stable forms that are specified early in the transcription cycle and isomerize to other forms slowly. In contrast, equilibrium or rapid interconversion models require that active elongation complexes interconvert rapidly on the time-scale of single nucleotide addition. Measurements of transcription termination efficiency (TE) can be used to distinguish between these models, because stable heterogeneity models predict that the termination-resistant fraction of an elongation complex population should be enriched after transcription through an upstream terminator, leading to a decreased TE at downstream terminators. In contrast, rapid interconversion models require that the population of active (elongation-competent) complexes equilibrate after transcription through each terminator and, therefore, that the value of TE observed at identical upstream and downstream terminators should be the same. We have constructed transcription templates containing multiple identical terminators and found no significant changes in TE with terminator position along the template. Various other forms of upstream treatment of elongation complex populations also were used to attempt to fractionate the complexes into functionally different forms. None of these treatments changed the apparent TE at downstream terminators. These results are consistent with a rapid interconversion model of transcript elongation. The consequences of these results for the regulation of gene expression are discussed." @default.
• W2024677687 created "2016-06-24" @default.
• W2024677687 creator A5035447333 @default.
• W2024677687 creator A5068974470 @default.
• W2024677687 date "2002-09-01" @default.
• W2024677687 modified "2023-09-27" @default.
• W2024677687 title "Active Escherichia coli Transcription Elongation Complexes are Functionally Homogeneous" @default.
• W2024677687 cites W1575766761 @default.
• W2024677687 cites W1967475411 @default.
• W2024677687 cites W1970103400 @default.
• W2024677687 cites W1987568156 @default.
• W2024677687 cites W1989736935 @default.
• W2024677687 cites W2003778374 @default.
• W2024677687 cites W2015239171 @default.
• W2024677687 cites W2019277702 @default.
• W2024677687 cites W2023135381 @default.
• W2024677687 cites W2023204558 @default.
• W2024677687 cites W2024583069 @default.
• W2024677687 cites W2036001210 @default.
• W2024677687 cites W2037031854 @default.
• W2024677687 cites W2070316261 @default.
• W2024677687 cites W2096260627 @default.
• W2024677687 cites W2101583162 @default.
• W2024677687 cites W2113180123 @default.
• W2024677687 cites W2144962980 @default.
• W2024677687 cites W2163749025 @default.
• W2024677687 cites W2165289894 @default.
• W2024677687 cites W2167092674 @default.
• W2024677687 cites W2167164082 @default.
• W2024677687 doi "https://doi.org/10.1016/s0022-2836(02)00814-8" @default.
• W2024677687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12225745" @default.
• W2024677687 hasPublicationYear "2002" @default.
• W2024677687 type Work @default.
• W2024677687 sameAs 2024677687 @default.
• W2024677687 citedByCount "16" @default.
• W2024677687 countsByYear W20246776872014 @default.
• W2024677687 countsByYear W20246776872017 @default.
• W2024677687 countsByYear W20246776872021 @default.
• W2024677687 crossrefType "journal-article" @default.
• W2024677687 hasAuthorship W2024677687A5035447333 @default.
• W2024677687 hasAuthorship W2024677687A5068974470 @default.
• W2024677687 hasConcept C104317684 @default.
• W2024677687 hasConcept C112950240 @default.
• W2024677687 hasConcept C116403925 @default.
• W2024677687 hasConcept C121332964 @default.
• W2024677687 hasConcept C12554922 @default.
• W2024677687 hasConcept C1276947 @default.
• W2024677687 hasConcept C138885662 @default.
• W2024677687 hasConcept C139124968 @default.
• W2024677687 hasConcept C144024400 @default.
• W2024677687 hasConcept C149923435 @default.
• W2024677687 hasConcept C178046730 @default.
• W2024677687 hasConcept C179926584 @default.
• W2024677687 hasConcept C191897082 @default.
• W2024677687 hasConcept C192562407 @default.
• W2024677687 hasConcept C2908647359 @default.
• W2024677687 hasConcept C33947775 @default.
• W2024677687 hasConcept C41895202 @default.
• W2024677687 hasConcept C54355233 @default.
• W2024677687 hasConcept C67705224 @default.
• W2024677687 hasConcept C86803240 @default.
• W2024677687 hasConcept C88478588 @default.
• W2024677687 hasConcept C95444343 @default.
• W2024677687 hasConceptScore W2024677687C104317684 @default.
• W2024677687 hasConceptScore W2024677687C112950240 @default.
• W2024677687 hasConceptScore W2024677687C116403925 @default.
• W2024677687 hasConceptScore W2024677687C121332964 @default.
• W2024677687 hasConceptScore W2024677687C12554922 @default.
• W2024677687 hasConceptScore W2024677687C1276947 @default.
• W2024677687 hasConceptScore W2024677687C138885662 @default.
• W2024677687 hasConceptScore W2024677687C139124968 @default.
• W2024677687 hasConceptScore W2024677687C144024400 @default.
• W2024677687 hasConceptScore W2024677687C149923435 @default.
• W2024677687 hasConceptScore W2024677687C178046730 @default.
• W2024677687 hasConceptScore W2024677687C179926584 @default.
• W2024677687 hasConceptScore W2024677687C191897082 @default.
• W2024677687 hasConceptScore W2024677687C192562407 @default.
• W2024677687 hasConceptScore W2024677687C2908647359 @default.
• W2024677687 hasConceptScore W2024677687C33947775 @default.
• W2024677687 hasConceptScore W2024677687C41895202 @default.
• W2024677687 hasConceptScore W2024677687C54355233 @default.
• W2024677687 hasConceptScore W2024677687C67705224 @default.
• W2024677687 hasConceptScore W2024677687C86803240 @default.
• W2024677687 hasConceptScore W2024677687C88478588 @default.
• W2024677687 hasConceptScore W2024677687C95444343 @default.
• W2024677687 hasIssue "3" @default.
• W2024677687 hasLocation W20246776871 @default.
• W2024677687 hasLocation W20246776872 @default.
• W2024677687 hasOpenAccess W2024677687 @default.
• W2024677687 hasPrimaryLocation W20246776871 @default.
• W2024677687 hasRelatedWork W1520121840 @default.
• W2024677687 hasRelatedWork W1574548557 @default.
• W2024677687 hasRelatedWork W1760941140 @default.
• W2024677687 hasRelatedWork W1818003313 @default.
• W2024677687 hasRelatedWork W2024677687 @default.
• W2024677687 hasRelatedWork W2040237899 @default.
• W2024677687 hasRelatedWork W2043249063 @default.
• W2024677687 hasRelatedWork W2048874003 @default.

• next