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• W2024679408 abstract "The Arabidopsis thaliana tandem zinc finger 1 (AtTZF1) protein is characterized by two tandem-arrayed CCCH-type zinc fingers. We have previously found that AtTZF1 affects hormone-mediated growth, stress and gene expression responses. While much has been learned at the genetic and physiological level, the molecular mechanisms underlying the effects of AtTZF1 on gene expression remain obscure. A human TZF protein, hTTP, is known to bind and trigger the degradation of mRNAs containing AU-rich elements (AREs) at the 3' untranslated regions. However, while the TZF motif of hTTP is characterized by C(X8)C(X5)C(X3)H-(X18)-C(X8)C(X5)C(X3)H, AtTZF1 contains an atypical motif of C(X7)C(X5)C(X3)H-(X16)-C(X5)C(X4)C(X3)H. Moreover, the TZF motif of AtTZF1 is preceded by an arginine-rich (RR) region that is unique to plants. Using fluorescence anisotropy and electrophoretic mobility shift binding assays, we have demonstrated that AtTZF1 binds to RNA molecules with specificity and the interaction is dependent on the presence of zinc. Compared with hTTP, in which TZF is solely responsible for RNA binding, both TZF and RR regions of AtTZF1 are required to achieve high-affinity RNA binding. Moreover, zinc finger integrity is vital for RNA binding. Using a plant protoplast transient expression analysis we have further revealed that AtTZF1 can trigger the decay of ARE-containing mRNAs in vivo. Taken together, our results support the notion that AtTZF1 is involved in RNA turnover." @default.
• W2024679408 created "2016-06-24" @default.
• W2024679408 creator A5005933536 @default.
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• W2024679408 creator A5049506879 @default.
• W2024679408 creator A5053107773 @default.
• W2024679408 creator A5065431755 @default.
• W2024679408 date "2014-04-15" @default.
• W2024679408 modified "2023-10-17" @default.
• W2024679408 title "The<i>Arabidopsis thaliana</i>tandem zinc finger 1 (AtTZF1) protein in RNA binding and decay" @default.
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• W2024679408 doi "https://doi.org/10.1111/tpj.12485" @default.
• W2024679408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4026020" @default.
• W2024679408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24635033" @default.
• W2024679408 hasPublicationYear "2014" @default.
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