FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024679573> ?p ?o ?g. }

• W2024679573 endingPage "1435" @default.
• W2024679573 startingPage "1425" @default.
• W2024679573 abstract "Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have previously reported that transgenic mice expressing exon 1 of the human Huntington gene (R6 lines) are resistant to quinolinic acid-induced striatal toxicity. In this study we show that with increasing age, R6/1 and R6/2 mice develop partial resistance to DA- and 6-hydroxydopamine-mediated toxicity in the striatum. Using electron microscopy, we found that the resistance is localized to the cell bodies and not to the neuropil. The reduction of dopamine and cAMP regulated phosphoprotein of a molecular weight of 32 kDa (DARPP-32) in R6/2 mice does not provide the resistance, as DA-induced striatal lesions are not reduced in size in DARPP-32 knockout mice. Neither DA receptor antagonists nor a N-methyl-d-aspartate (NMDA) receptor blocker reduce the size of DA-induced striatal lesions, suggesting that DA toxicity is not dependent upon DA- or NMDA receptor-mediated pathways. Moreover, superoxide dismutase-1 overexpression, monoamine oxidase inhibition and the treatment with the free radical scavenging spin-trap agent phenyl-butyl-tert-nitrone (PBN) also did not block DA toxicity. Levels of the antioxidant molecules, glutathione and ascorbate were not increased in R6/1 mice. Because damage to striatal neurons following intrastriatal injection of 6-hydroxydopamine was also reduced in R6 mice, a yet-to-be identified antioxidant mechanism may provide neuroprotection in these animals. We conclude that striatal neurons of R6 mice develop resistance to DA-induced toxicity with age." @default.
• W2024679573 created "2016-06-24" @default.
• W2024679573 creator A5026787858 @default.
• W2024679573 creator A5027139411 @default.
• W2024679573 creator A5043025373 @default.
• W2024679573 creator A5048341976 @default.
• W2024679573 creator A5049277633 @default.
• W2024679573 creator A5055526480 @default.
• W2024679573 creator A5057571524 @default.
• W2024679573 creator A5064753559 @default.
• W2024679573 creator A5072622786 @default.
• W2024679573 creator A5089607612 @default.
• W2024679573 creator A5089901938 @default.
• W2024679573 date "2001-11-01" @default.
• W2024679573 modified "2023-10-09" @default.
• W2024679573 title "Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine" @default.
• W2024679573 cites W1512006538 @default.
• W2024679573 cites W1681161665 @default.
• W2024679573 cites W1780016128 @default.
• W2024679573 cites W1940885739 @default.
• W2024679573 cites W1964237517 @default.
• W2024679573 cites W1966748491 @default.
• W2024679573 cites W1975938614 @default.
• W2024679573 cites W1979308658 @default.
• W2024679573 cites W1979480763 @default.
• W2024679573 cites W1998974178 @default.
• W2024679573 cites W2002630545 @default.
• W2024679573 cites W2011805483 @default.
• W2024679573 cites W2014746376 @default.
• W2024679573 cites W2016293448 @default.
• W2024679573 cites W2021054343 @default.
• W2024679573 cites W2022829791 @default.
• W2024679573 cites W2026793631 @default.
• W2024679573 cites W2035820503 @default.
• W2024679573 cites W2036211037 @default.
• W2024679573 cites W2042716629 @default.
• W2024679573 cites W2046193852 @default.
• W2024679573 cites W2048484492 @default.
• W2024679573 cites W2054855746 @default.
• W2024679573 cites W2062682951 @default.
• W2024679573 cites W2063375748 @default.
• W2024679573 cites W2065000444 @default.
• W2024679573 cites W2072396956 @default.
• W2024679573 cites W2074113747 @default.
• W2024679573 cites W2074128319 @default.
• W2024679573 cites W2075326685 @default.
• W2024679573 cites W2084849755 @default.
• W2024679573 cites W2087399615 @default.
• W2024679573 cites W2088778752 @default.
• W2024679573 cites W2089338632 @default.
• W2024679573 cites W2092492531 @default.
• W2024679573 cites W2100668419 @default.
• W2024679573 cites W2101316941 @default.
• W2024679573 cites W2103134692 @default.
• W2024679573 cites W2104064731 @default.
• W2024679573 cites W2105382539 @default.
• W2024679573 cites W2107522917 @default.
• W2024679573 cites W2110715131 @default.
• W2024679573 cites W2122440289 @default.
• W2024679573 cites W2125248031 @default.
• W2024679573 cites W2131155959 @default.
• W2024679573 cites W2138152051 @default.
• W2024679573 cites W2146439993 @default.
• W2024679573 cites W2170453612 @default.
• W2024679573 cites W2170726804 @default.
• W2024679573 cites W2200286821 @default.
• W2024679573 cites W4206144694 @default.
• W2024679573 doi "https://doi.org/10.1046/j.0953-816x.2001.01765.x" @default.
• W2024679573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11722604" @default.
• W2024679573 hasPublicationYear "2001" @default.
• W2024679573 type Work @default.
• W2024679573 sameAs 2024679573 @default.
• W2024679573 citedByCount "43" @default.
• W2024679573 countsByYear W20246795732012 @default.
• W2024679573 countsByYear W20246795732014 @default.
• W2024679573 countsByYear W20246795732015 @default.
• W2024679573 countsByYear W20246795732016 @default.
• W2024679573 countsByYear W20246795732019 @default.
• W2024679573 countsByYear W20246795732022 @default.
• W2024679573 crossrefType "journal-article" @default.
• W2024679573 hasAuthorship W2024679573A5026787858 @default.
• W2024679573 hasAuthorship W2024679573A5027139411 @default.
• W2024679573 hasAuthorship W2024679573A5043025373 @default.
• W2024679573 hasAuthorship W2024679573A5048341976 @default.
• W2024679573 hasAuthorship W2024679573A5049277633 @default.
• W2024679573 hasAuthorship W2024679573A5055526480 @default.
• W2024679573 hasAuthorship W2024679573A5057571524 @default.
• W2024679573 hasAuthorship W2024679573A5064753559 @default.
• W2024679573 hasAuthorship W2024679573A5072622786 @default.
• W2024679573 hasAuthorship W2024679573A5089607612 @default.
• W2024679573 hasAuthorship W2024679573A5089901938 @default.
• W2024679573 hasConcept C126322002 @default.
• W2024679573 hasConcept C134018914 @default.
• W2024679573 hasConcept C137183658 @default.
• W2024679573 hasConcept C185592680 @default.
• W2024679573 hasConcept C25498285 @default.
• W2024679573 hasConcept C2776706248 @default.
• W2024679573 hasConcept C2776925932 @default.

• next