Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024683407> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2024683407 endingPage "488" @default.
- W2024683407 startingPage "485" @default.
- W2024683407 abstract "Aconitase catalyzes a reversible isomerization of citrate into isocitrate in the Krebs cycle. Escherichia coli possesses two kinds of aconitases, aconitase A (AcnA) and B (AcnB), whose structural organizations are different. We analyzed the structural state of AcnA by the chemical crosslinking and small-angle X-ray scattering. The protein adopts a homodimer in solution, as AcnB does. The catalytic assay of the two aconitases revealed that the isomerization of isocitrate displayed a negative cooperativity of the two active sites within each homodimer. On the other hand, insignificant cooperativity was observed in the reverse reaction. Therefore, the homodimerization of AcnAB yields a substrate-dependent cooperative effect. In conjunction with the dissociable homodimer of AcnB, the catalytic property could affect the intracellular metabolic process involving the Krebs cycle." @default.
- W2024683407 created "2016-06-24" @default.
- W2024683407 creator A5015575713 @default.
- W2024683407 creator A5051383537 @default.
- W2024683407 creator A5063900429 @default.
- W2024683407 date "2009-02-01" @default.
- W2024683407 modified "2023-09-27" @default.
- W2024683407 title "Cooperativity of two active sites in bacterial homodimeric aconitases" @default.
- W2024683407 cites W1560313356 @default.
- W2024683407 cites W1977038370 @default.
- W2024683407 cites W2013083986 @default.
- W2024683407 cites W2018789831 @default.
- W2024683407 cites W2020961593 @default.
- W2024683407 cites W2058191052 @default.
- W2024683407 cites W2066088601 @default.
- W2024683407 cites W2068378745 @default.
- W2024683407 cites W2072674961 @default.
- W2024683407 cites W2113204163 @default.
- W2024683407 cites W2147189708 @default.
- W2024683407 cites W4240946636 @default.
- W2024683407 doi "https://doi.org/10.1016/j.bbrc.2008.12.096" @default.
- W2024683407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19116142" @default.
- W2024683407 hasPublicationYear "2009" @default.
- W2024683407 type Work @default.
- W2024683407 sameAs 2024683407 @default.
- W2024683407 citedByCount "7" @default.
- W2024683407 countsByYear W20246834072013 @default.
- W2024683407 countsByYear W20246834072014 @default.
- W2024683407 countsByYear W20246834072017 @default.
- W2024683407 countsByYear W20246834072023 @default.
- W2024683407 crossrefType "journal-article" @default.
- W2024683407 hasAuthorship W2024683407A5015575713 @default.
- W2024683407 hasAuthorship W2024683407A5051383537 @default.
- W2024683407 hasAuthorship W2024683407A5063900429 @default.
- W2024683407 hasConcept C12554922 @default.
- W2024683407 hasConcept C126661725 @default.
- W2024683407 hasConcept C161790260 @default.
- W2024683407 hasConcept C166014724 @default.
- W2024683407 hasConcept C181199279 @default.
- W2024683407 hasConcept C185592680 @default.
- W2024683407 hasConcept C200886947 @default.
- W2024683407 hasConcept C41183919 @default.
- W2024683407 hasConcept C55493867 @default.
- W2024683407 hasConcept C71240020 @default.
- W2024683407 hasConcept C79879829 @default.
- W2024683407 hasConcept C86803240 @default.
- W2024683407 hasConceptScore W2024683407C12554922 @default.
- W2024683407 hasConceptScore W2024683407C126661725 @default.
- W2024683407 hasConceptScore W2024683407C161790260 @default.
- W2024683407 hasConceptScore W2024683407C166014724 @default.
- W2024683407 hasConceptScore W2024683407C181199279 @default.
- W2024683407 hasConceptScore W2024683407C185592680 @default.
- W2024683407 hasConceptScore W2024683407C200886947 @default.
- W2024683407 hasConceptScore W2024683407C41183919 @default.
- W2024683407 hasConceptScore W2024683407C55493867 @default.
- W2024683407 hasConceptScore W2024683407C71240020 @default.
- W2024683407 hasConceptScore W2024683407C79879829 @default.
- W2024683407 hasConceptScore W2024683407C86803240 @default.
- W2024683407 hasIssue "2" @default.
- W2024683407 hasLocation W20246834071 @default.
- W2024683407 hasLocation W20246834072 @default.
- W2024683407 hasOpenAccess W2024683407 @default.
- W2024683407 hasPrimaryLocation W20246834071 @default.
- W2024683407 hasRelatedWork W1967645763 @default.
- W2024683407 hasRelatedWork W1973387999 @default.
- W2024683407 hasRelatedWork W2320277076 @default.
- W2024683407 hasRelatedWork W2363498292 @default.
- W2024683407 hasRelatedWork W2395773616 @default.
- W2024683407 hasRelatedWork W2605206679 @default.
- W2024683407 hasRelatedWork W2949226866 @default.
- W2024683407 hasRelatedWork W2952183763 @default.
- W2024683407 hasRelatedWork W3004986603 @default.
- W2024683407 hasRelatedWork W4238592385 @default.
- W2024683407 hasVolume "379" @default.
- W2024683407 isParatext "false" @default.
- W2024683407 isRetracted "false" @default.
- W2024683407 magId "2024683407" @default.
- W2024683407 workType "article" @default.