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- W2024684095 abstract "Experimental allergic encephalomyelitis (EAE) in Lewis rats is an acute monophasic autoimmune disease. It can be treated prophylactically and therapeutically with high doses of cyclosporin A (CsA). Here we demonstrate that low-dose CsA does not prevent a first attack of EAE, but, on the contrary, induces a chronic relapsing form of the disease in 100% of Lewis rats examined. Possible explanations for the high relapse rate after low-dose CsA treatment are discussed. Further studies will be needed to evaluate the immunological mechanisms responsible for these results." @default.
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- W2024684095 date "1988-02-01" @default.
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- W2024684095 title "Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat" @default.
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- W2024684095 doi "https://doi.org/10.1016/0165-5728(88)90069-0" @default.
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