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• W2024685462 abstract "Oil pollution from various sources, including exploration, production and transportation, is a growing global concern. The highest toxicity of hydrocarbon pollutants is associated with the water-soluble phase compounds, including naphthenic acids, a known component found in all hydrocarbon deposits. Recently, naphthenic acids (NAs) have shown estrogenic and anti-androgenic effects in vitro. For this reason we investigated the potential effects of two commercial mixtures of naphthenic acids on fish in vivo, using the three-spined stickleback (Gasterosteus aculeatus) as a model species. Anti-androgenic and estrogenic properties of tested compounds were evaluated using the androgenized female stickleback screen (AFSS) and a variant of the 21-d fish screen (TG230) respectively. One-dimensional gas chromatography-mass spectrometry (GC-MS) showed that the complex commercial NAs mixtures were dominated by acyclic carboxylic acids. In one experiment (freshwater) we found a clear effect of NA exposure on spiggin levels; this was contrary to our hypothesis since NAs enhanced the androgenic potency of DHT (when co-administered) without inducing spiggin when tested in the absence of DHT. Exposure to NAs did not have a statistically significant effect on vitellogenin (Vtg) production in male stickleback, although the Vtg responses were increasing with increasing exposure concentrations. This study shows that in contrast to previous in vitro data, NAs did not exhibit either estrogenic or anti-androgenic properties in vivo, at the concentrations tested. On the contrary, at least in freshwater, NAs appear to have an overall androgenic effect that is not mediated via the androgen receptor involved in spiggin synthesis. Possible reasons for this discrepancy between in vitro and in vivo results as well as between our studies are discussed." @default.
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• W2024685462 date "2013-11-01" @default.
• W2024685462 modified "2023-09-25" @default.
• W2024685462 title "In vivo endocrine effects of naphthenic acids in fish" @default.
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• W2024685462 doi "https://doi.org/10.1016/j.chemosphere.2013.08.033" @default.
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