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• W2024685706 abstract "The farnesoid X receptor/bile acid receptor (FXR) is a recently discovered member of the nuclear hormone superfamily. FXR ligands have been proposed as targets in cardiovascular disease, regulating cholesterol metabolism and bile acid transport and metabolism in the liver and gastrointestinal tract. When we used a human cardiovascular tissue array, we found that FXR is expressed in a variety of normal and pathological human tissue. Particularly high levels of FXR were found in the vasculature and in a number of different metastatic cancers, as well as the previously identified target tissues of the liver, small intestine, and kidney. In vitro, FXR is present in rat and human vascular smooth muscle cells. When treated with a range of FXR ligands, vascular smooth muscle cells undergo apoptosis in a manner that correlates with the ligands' ability to activate FXR. Furthermore, FXR activators induce mRNA for the FXR target genes, phospholipid transfer protein, and the small heterodimer partner. FXR therefore is a functional protein in the vasculature that may provide a direct target for the treatment of proliferative and dyslipidaemic diseases." @default.
• W2024685706 created "2016-06-24" @default.
• W2024685706 creator A5049732997 @default.
• W2024685706 creator A5065279271 @default.
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• W2024685706 date "2004-02-27" @default.
• W2024685706 modified "2023-10-16" @default.
• W2024685706 title "Expression and activation of the farnesoid X receptor in the vasculature" @default.
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• W2024685706 doi "https://doi.org/10.1073/pnas.0400046101" @default.
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