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• W2024688253 abstract "The mechanism of potentiation of mechanical activity by tetraethylammonium : loride (TEA) was investigated in canine tracheal smooth muscle. Twitch tension induced by direct electrical stimulation was potentiated by 1 mM TEA to more than twice the amplitude. Although the tracheal strips usually exhibited no myogenic response to quick stretch, application of TEA (≧10 mM) produced myogenic responses to quick stretch. This response, however, could be induced in the presence of less than 3 mM TEA in a solution containing 10.9 or 15.9 mM potassium. TEA (2 mM) significantly :Dtentiated the contraction induced by 20 mM potassium, and the potentiation was not :oserved in the absence of calcium ion. On the other hand, 2 mM TEA did not potentiated the contraction induced by CaCI2 in strongly depolarized muscle. Tetramethyl- (TMA) and tetrapropylammonium (TPA) did not produce myogenic responses to quick stretch, and there was no potentiating effect on the responses to direct electrical stimulation or :o high levels of potassium. The blocking activity of these two ammonium ions on 86Rb-efflux was considerably less than seen with TEA. In conclusion, the blocking of potassium conductance by TEA, even at concentrations lower than 5 mM, results in the increase in Ca conductance when electrically, mechanically or chemically stimulated. TEA probably increased the transmembrane Ca-influx as a result of the potentiation of cell membrane depolarization." @default.
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• W2024688253 date "1983-01-01" @default.
• W2024688253 modified "2023-09-23" @default.
• W2024688253 title "Mechanism of potentiation of mechanical responses by tetraethylammonium in canine tracheal smooth muscle." @default.
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• W2024688253 doi "https://doi.org/10.1254/jjp.33.155" @default.
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