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- W2024689132 abstract "A short review is presented of the published positive and negative results obtained with sodium alginate to reduce selectively the intestinal absorption of Sr, and of the chemical properties of alginate supposed to underlie this inhibition. Data are presented on the high efficiency of sodium alginate to diminish the absorption of 226Ra: when a meal of alginated bread was given 2 hr before the administration by gastric tube of a 226RaCl2 solution, the Ra-uptake in mice was reduced more than a hundredfold. In the same experiment 47Ca-uptake was reduced to only 1.2 times less than in the control animals. The effects on 226Ra-absorption of different alginates, of intestinal filling with standard diet or with agar gel and of fasting are compared. The use of a coaxial Ge(Li) detector coupled with a translating and rotating sample handler allowed the direct in vivo measurement of the body-burden of 226Ra and 47Ca in the same animal. The shape of the retention curve of 226Ra with, and without preventive alginate treatment could thus be compared. Starting 2 hr (= 1/4 of the transit time through the G.I. tract) after an intubation of 226Ra, a therapeutic and chronic alginate treatment both reduced directly the body burden and enhanced slightly the rate of loss of 226Ra. The body retention curves of 226Ra are interpreted as a sequence of three different exponential loss rates." @default.
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- W2024689132 title "Intestinal Absorption and Body Retention of 226-Radium and 47-Calcium in Mice" @default.
- W2024689132 doi "https://doi.org/10.1097/00004032-197108000-00004" @default.
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