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• W2024690908 abstract "Abstract The hexokinase-acceptor theory of insulin action is described and evidence for its validity is discussed. The theory states that insulin acts by connecting hexokinase to mitochondria. The close association of this particular enzyme to specific energy generating sites stimulates energy generation by the process known as respiratory control. The ADP generated when mitochondrial ATP is utilized by hexokinase to phosphorylate glucose acts as a stimulus — substrate — for further ATP generation by the Krebs cycle. The close proximity of the enzymes to the sites of energy generation makes the process of energy generation more efficient, providing more energy for anabolic reactions, all of which are stimulated by insulin. The lack of insulin effect on brain results from the fact that hexokinase in brain is tightly bound to mitochondria. On the other hand, the requirement of glucose for energy production in brain is evidence for the functional significance of this binding of hexokinase. The insulin-like effect of exercise in the diabetic is seen in the light of this theory as an acceptor effect of creatine liberated by muscle contraction." @default.
• W2024690908 created "2016-06-24" @default.
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• W2024690908 date "1975-04-01" @default.
• W2024690908 modified "2023-09-23" @default.
• W2024690908 title "The hexokinase acceptor theory of insulin action — Hormonal control of functional compartmentation" @default.
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• W2024690908 doi "https://doi.org/10.1016/0024-3205(75)90306-9" @default.
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