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- W2024694751 abstract "Several derivatives with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain were synthesized. Compounds that had an electron-donating group exhibited high affinity for the μ opioid receptor while those with a bulky substituent at the 8-nitrogen atom had low affinities for all receptor types. High affinities and selectivities for the κ receptor resulted from the introduction of the longer amide side chain at the 7α-position. Our studies indicate that the orientation of the amide side chain at the 7-position within the azabicyclo[2.2.2]octane skeleton is related to selectivity for the κ receptor." @default.
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- W2024694751 date "2013-06-01" @default.
- W2024694751 modified "2023-10-14" @default.
- W2024694751 title "Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies" @default.
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- W2024694751 doi "https://doi.org/10.1016/j.bmc.2013.03.026" @default.
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