Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024695743> ?p ?o ?g. }
- W2024695743 endingPage "4476" @default.
- W2024695743 startingPage "4476" @default.
- W2024695743 abstract "Purpose.: Ischemic insults give rise to severe visual deficits after blood vessel occlusion. In this study we investigated the effects of retinal stroke on the direction-selective circuit of the inner retina in a new adult mouse model. Methods.: The inner retinal blood flow was interrupted for 60 minutes by ligating the ophthalmic arteries and veins in the optic nerve sheath. The optokinetic response (OKR) was measured to assess ischemia/reperfusion-mediated functional deficits and structural changes were studied by immunohistochemistry. Results.: Ischemia/reperfusion induced reactive gliosis and degeneration of the inner retina. The OKR was almost completely abolished from 7 days after reperfusion, whereas approximately 40% of retinal ganglion cells were still alive. Ischemia led to severe degeneration of the processes of starburst amacrine cells (SAC), which cell bodies are in the ganglion cell layer (ON SACs), and to a lesser extent of the dendrites of SACs, which cell bodies are in the inner nuclear layer (OFF SACs). In addition, the elimination of retinal ganglion cells, direction-selective ganglion cells, and ON SACs was much greater at 10 days and 21 days than that of OFF SACs. After reperfusion, P-Stat3 was transiently activated in ganglion cells, whereas P-Erk1/2 signal was specifically detected in Müller glia. Conclusions.: These results show a pronounced destruction of the ON direction-selective circuit in the inner retina that correlated with the irreversible loss of the OKR early after ischemia/reperfusion." @default.
- W2024695743 created "2016-06-24" @default.
- W2024695743 creator A5025502296 @default.
- W2024695743 creator A5044916522 @default.
- W2024695743 creator A5057817479 @default.
- W2024695743 creator A5058015185 @default.
- W2024695743 date "2014-07-21" @default.
- W2024695743 modified "2023-09-23" @default.
- W2024695743 title "New Mouse Retinal Stroke Model Reveals Direction-Selective Circuit Damage Linked to Permanent Optokinetic Response Loss" @default.
- W2024695743 cites W1605339647 @default.
- W2024695743 cites W1951518708 @default.
- W2024695743 cites W1966053934 @default.
- W2024695743 cites W1967364872 @default.
- W2024695743 cites W1971502700 @default.
- W2024695743 cites W1972182447 @default.
- W2024695743 cites W1973069509 @default.
- W2024695743 cites W1977423618 @default.
- W2024695743 cites W1982422365 @default.
- W2024695743 cites W1983161016 @default.
- W2024695743 cites W1989150914 @default.
- W2024695743 cites W1996011223 @default.
- W2024695743 cites W1996384089 @default.
- W2024695743 cites W1997391162 @default.
- W2024695743 cites W2003899473 @default.
- W2024695743 cites W2011066824 @default.
- W2024695743 cites W2012740881 @default.
- W2024695743 cites W2012848199 @default.
- W2024695743 cites W2016554865 @default.
- W2024695743 cites W2017253782 @default.
- W2024695743 cites W2020934096 @default.
- W2024695743 cites W2022074111 @default.
- W2024695743 cites W2023281063 @default.
- W2024695743 cites W2024419580 @default.
- W2024695743 cites W2026755389 @default.
- W2024695743 cites W2026838101 @default.
- W2024695743 cites W2029207368 @default.
- W2024695743 cites W2030222823 @default.
- W2024695743 cites W2031345309 @default.
- W2024695743 cites W2034819951 @default.
- W2024695743 cites W2038674056 @default.
- W2024695743 cites W2039127036 @default.
- W2024695743 cites W2040386224 @default.
- W2024695743 cites W2040463826 @default.
- W2024695743 cites W2044143665 @default.
- W2024695743 cites W2047315977 @default.
- W2024695743 cites W2047727597 @default.
- W2024695743 cites W2047990013 @default.
- W2024695743 cites W2048450239 @default.
- W2024695743 cites W2050174076 @default.
- W2024695743 cites W2053221182 @default.
- W2024695743 cites W2055820698 @default.
- W2024695743 cites W2055878329 @default.
- W2024695743 cites W2056790943 @default.
- W2024695743 cites W2057871269 @default.
- W2024695743 cites W2059932450 @default.
- W2024695743 cites W2060470755 @default.
- W2024695743 cites W2064836052 @default.
- W2024695743 cites W2067215757 @default.
- W2024695743 cites W2073324143 @default.
- W2024695743 cites W2074708561 @default.
- W2024695743 cites W2076736059 @default.
- W2024695743 cites W2080816502 @default.
- W2024695743 cites W2084450839 @default.
- W2024695743 cites W2084737247 @default.
- W2024695743 cites W2086262115 @default.
- W2024695743 cites W2089264102 @default.
- W2024695743 cites W2089802537 @default.
- W2024695743 cites W2090336874 @default.
- W2024695743 cites W2094467372 @default.
- W2024695743 cites W2106641866 @default.
- W2024695743 cites W2108555500 @default.
- W2024695743 cites W2138084996 @default.
- W2024695743 cites W2140017053 @default.
- W2024695743 cites W2142850882 @default.
- W2024695743 cites W2146819974 @default.
- W2024695743 cites W2147624068 @default.
- W2024695743 cites W2160101241 @default.
- W2024695743 cites W2164913239 @default.
- W2024695743 cites W230878719 @default.
- W2024695743 cites W50296032 @default.
- W2024695743 cites W53459579 @default.
- W2024695743 cites W60487933 @default.
- W2024695743 cites W653329761 @default.
- W2024695743 doi "https://doi.org/10.1167/iovs.14-14521" @default.
- W2024695743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24970264" @default.
- W2024695743 hasPublicationYear "2014" @default.
- W2024695743 type Work @default.
- W2024695743 sameAs 2024695743 @default.
- W2024695743 citedByCount "11" @default.
- W2024695743 countsByYear W20246957432015 @default.
- W2024695743 countsByYear W20246957432016 @default.
- W2024695743 countsByYear W20246957432017 @default.
- W2024695743 countsByYear W20246957432018 @default.
- W2024695743 countsByYear W20246957432020 @default.
- W2024695743 countsByYear W20246957432022 @default.
- W2024695743 countsByYear W20246957432023 @default.
- W2024695743 crossrefType "journal-article" @default.
- W2024695743 hasAuthorship W2024695743A5025502296 @default.