Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024696492> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2024696492 endingPage "498a" @default.
- W2024696492 startingPage "498a" @default.
- W2024696492 abstract "Atomistic molecular dynamics simulations were used to investigate the interactions between the neurotransmitter dopamine and its precursor L-dopa with membrane lipids. The results indicate that these molecules strongly interact with the lipid head groups e.g. via hydrogen bonds. These interactions anchor the dopamine and L-dopa to the membrane interfacial region. The strength of this bonding is dependent on lipids present in membrane. Presence of phosphatidylserine resulted in increased level of bonding strength with a lifetime longer than the timescale of our simulations. The high membrane association of dopamine and L-dopa both, extracellularly, might favour the availability of these compounds for cell membrane uptake processes and, intracellularly, can accentuate the importance of membrane-bound metabolizing enzymes over their soluble counterparts. We can also hypothesize that excessive association of dopamine and its precursor L-dopa with the membranes in the situation, when the concentration of phosphatidylserine is increased, may eventually limit the free use of dopamine as a synaptic transmitter what could possibly be a molecular level mechanism responsible for some of neurodegenerative disorders." @default.
- W2024696492 created "2016-06-24" @default.
- W2024696492 creator A5013538677 @default.
- W2024696492 creator A5016682467 @default.
- W2024696492 creator A5029212835 @default.
- W2024696492 creator A5052092699 @default.
- W2024696492 creator A5055479387 @default.
- W2024696492 creator A5057870224 @default.
- W2024696492 creator A5082983574 @default.
- W2024696492 date "2013-01-01" @default.
- W2024696492 modified "2023-10-16" @default.
- W2024696492 title "The Interactions of Dopamine and L-Dopa with Lipid Headgroup and its Implication for Neurotransmitters Metabolism" @default.
- W2024696492 doi "https://doi.org/10.1016/j.bpj.2012.11.2748" @default.
- W2024696492 hasPublicationYear "2013" @default.
- W2024696492 type Work @default.
- W2024696492 sameAs 2024696492 @default.
- W2024696492 citedByCount "0" @default.
- W2024696492 crossrefType "journal-article" @default.
- W2024696492 hasAuthorship W2024696492A5013538677 @default.
- W2024696492 hasAuthorship W2024696492A5016682467 @default.
- W2024696492 hasAuthorship W2024696492A5029212835 @default.
- W2024696492 hasAuthorship W2024696492A5052092699 @default.
- W2024696492 hasAuthorship W2024696492A5055479387 @default.
- W2024696492 hasAuthorship W2024696492A5057870224 @default.
- W2024696492 hasAuthorship W2024696492A5082983574 @default.
- W2024696492 hasBestOaLocation W20246964921 @default.
- W2024696492 hasConcept C12554922 @default.
- W2024696492 hasConcept C169760540 @default.
- W2024696492 hasConcept C170493617 @default.
- W2024696492 hasConcept C185592680 @default.
- W2024696492 hasConcept C2776219046 @default.
- W2024696492 hasConcept C2778106830 @default.
- W2024696492 hasConcept C2778918659 @default.
- W2024696492 hasConcept C2779637612 @default.
- W2024696492 hasConcept C41625074 @default.
- W2024696492 hasConcept C513476851 @default.
- W2024696492 hasConcept C55493867 @default.
- W2024696492 hasConcept C86803240 @default.
- W2024696492 hasConceptScore W2024696492C12554922 @default.
- W2024696492 hasConceptScore W2024696492C169760540 @default.
- W2024696492 hasConceptScore W2024696492C170493617 @default.
- W2024696492 hasConceptScore W2024696492C185592680 @default.
- W2024696492 hasConceptScore W2024696492C2776219046 @default.
- W2024696492 hasConceptScore W2024696492C2778106830 @default.
- W2024696492 hasConceptScore W2024696492C2778918659 @default.
- W2024696492 hasConceptScore W2024696492C2779637612 @default.
- W2024696492 hasConceptScore W2024696492C41625074 @default.
- W2024696492 hasConceptScore W2024696492C513476851 @default.
- W2024696492 hasConceptScore W2024696492C55493867 @default.
- W2024696492 hasConceptScore W2024696492C86803240 @default.
- W2024696492 hasIssue "2" @default.
- W2024696492 hasLocation W20246964921 @default.
- W2024696492 hasOpenAccess W2024696492 @default.
- W2024696492 hasPrimaryLocation W20246964921 @default.
- W2024696492 hasRelatedWork W1575105191 @default.
- W2024696492 hasRelatedWork W1581438400 @default.
- W2024696492 hasRelatedWork W2006858866 @default.
- W2024696492 hasRelatedWork W2024696492 @default.
- W2024696492 hasRelatedWork W2027484237 @default.
- W2024696492 hasRelatedWork W2048155008 @default.
- W2024696492 hasRelatedWork W2124013884 @default.
- W2024696492 hasRelatedWork W2161536338 @default.
- W2024696492 hasRelatedWork W2169744378 @default.
- W2024696492 hasRelatedWork W950194781 @default.
- W2024696492 hasVolume "104" @default.
- W2024696492 isParatext "false" @default.
- W2024696492 isRetracted "false" @default.
- W2024696492 magId "2024696492" @default.
- W2024696492 workType "article" @default.