FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024697358> ?p ?o ?g. }

• W2024697358 endingPage "1367" @default.
• W2024697358 startingPage "1353" @default.
• W2024697358 abstract "Objective: To compare the efficacy of rofecoxib and celecoxib for the treatment of knee or hip OA over 6 weeks.Methods: Two similarly designed, multicenter, randomized, double-blind, placebo-controlled studies. Patients were randomly assigned 3:3:3:1 in Study 1 to once daily (QD) rofecoxib 12.5 mg (N = 456), rofecoxib 25 mg (N = 459), celecoxib 200 mg (N = 456), or placebo (N = 150) and 3:3:1 in Study 2 to QD rofecoxib 25 mg (N = 471), celecoxib 200 mg (N = 460), or placebo (N = 151). There was no rofecoxib 12.5 mg arm in Study 2. The primary outcome measure of both studies was pain at night over 6 weeks for rofecoxib 25 mg vs. celecoxib 200 mg. Efficacy comparisons with rofecoxib 12.5 mg in Study 1 were included as pre-specified study objectives but not as pre-specified study hypotheses. Secondary endpoints included Patient Global Assessment of Response to Therapy (PGART) over 6 weeks and over 1 week. Safety was evaluated through the assessment of spontaneously reported adverse experiences (AEs), evaluation of vital signs, and laboratory data reported by investigators and patients.Results: For the primary endpoint, reduction in pain at night over 6 weeks in Study 1 was not significantly different between active treatments; in Study 2 rofecoxib 25 mg significantly ( p = 0.023) reduced pain at night compared with celecoxib 200 mg over 6 weeks. For the secondary endpoints, in both studies, significantly ( p < 0.05) more patients treated with rofecoxib 25 mg than celecoxib 200 mg had a good or excellent PGART over 6 weeks, and over the first week ( p < 0.01). In both studies, there were no significant differences between active medications in the incidence of reported overall, serious, or drug-related AEs. The reported AE rates with the active treatments were generally similar to those with placebo in the two studies.Conclusions: Rofecoxib 25 mg was significantly better than celecoxib 200 mg in relieving night pain at 6 weeks in one study; this was not confirmed in the accompanying study." @default.
• W2024697358 created "2016-06-24" @default.
• W2024697358 creator A5007653088 @default.
• W2024697358 creator A5023716582 @default.
• W2024697358 creator A5052221041 @default.
• W2024697358 creator A5064599465 @default.
• W2024697358 creator A5082536629 @default.
• W2024697358 creator A5090460841 @default.
• W2024697358 date "2006-06-08" @default.
• W2024697358 modified "2023-09-23" @default.
• W2024697358 title "Rofecoxib 12.5 mg, rofecoxib 25 mg, and celecoxib 200 mg in the treatment of symptomatic osteoarthritis: results of two similarly designed studies" @default.
• W2024697358 cites W116638456 @default.
• W2024697358 cites W144247879 @default.
• W2024697358 cites W1780627874 @default.
• W2024697358 cites W1978433400 @default.
• W2024697358 cites W1983104516 @default.
• W2024697358 cites W1983398430 @default.
• W2024697358 cites W1991350847 @default.
• W2024697358 cites W1992824602 @default.
• W2024697358 cites W1996170155 @default.
• W2024697358 cites W1997642392 @default.
• W2024697358 cites W2006417425 @default.
• W2024697358 cites W2011487877 @default.
• W2024697358 cites W2027140482 @default.
• W2024697358 cites W2040872866 @default.
• W2024697358 cites W2047819833 @default.
• W2024697358 cites W2052783645 @default.
• W2024697358 cites W2061772323 @default.
• W2024697358 cites W2065689558 @default.
• W2024697358 cites W2080325388 @default.
• W2024697358 cites W2084256772 @default.
• W2024697358 cites W2093048739 @default.
• W2024697358 cites W2094345617 @default.
• W2024697358 cites W2104379105 @default.
• W2024697358 cites W2108840350 @default.
• W2024697358 cites W2113498639 @default.
• W2024697358 cites W2116728057 @default.
• W2024697358 cites W2117227343 @default.
• W2024697358 cites W2117950795 @default.
• W2024697358 cites W2120165929 @default.
• W2024697358 cites W2123366546 @default.
• W2024697358 cites W2154476123 @default.
• W2024697358 cites W2158131645 @default.
• W2024697358 cites W2158968701 @default.
• W2024697358 cites W2162582390 @default.
• W2024697358 cites W2163481780 @default.
• W2024697358 cites W2312254686 @default.
• W2024697358 cites W2330496155 @default.
• W2024697358 cites W4245703231 @default.
• W2024697358 doi "https://doi.org/10.1185/030079906x104876" @default.
• W2024697358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16834834" @default.
• W2024697358 hasPublicationYear "2006" @default.
• W2024697358 type Work @default.
• W2024697358 sameAs 2024697358 @default.
• W2024697358 citedByCount "14" @default.
• W2024697358 countsByYear W20246973582012 @default.
• W2024697358 countsByYear W20246973582015 @default.
• W2024697358 countsByYear W20246973582017 @default.
• W2024697358 countsByYear W20246973582018 @default.
• W2024697358 countsByYear W20246973582019 @default.
• W2024697358 countsByYear W20246973582021 @default.
• W2024697358 crossrefType "journal-article" @default.
• W2024697358 hasAuthorship W2024697358A5007653088 @default.
• W2024697358 hasAuthorship W2024697358A5023716582 @default.
• W2024697358 hasAuthorship W2024697358A5052221041 @default.
• W2024697358 hasAuthorship W2024697358A5064599465 @default.
• W2024697358 hasAuthorship W2024697358A5082536629 @default.
• W2024697358 hasAuthorship W2024697358A5090460841 @default.
• W2024697358 hasConcept C126322002 @default.
• W2024697358 hasConcept C142724271 @default.
• W2024697358 hasConcept C181199279 @default.
• W2024697358 hasConcept C185592680 @default.
• W2024697358 hasConcept C197934379 @default.
• W2024697358 hasConcept C203092338 @default.
• W2024697358 hasConcept C204787440 @default.
• W2024697358 hasConcept C27081682 @default.
• W2024697358 hasConcept C2776164576 @default.
• W2024697358 hasConcept C2776467144 @default.
• W2024697358 hasConcept C2778582115 @default.
• W2024697358 hasConcept C2779689624 @default.
• W2024697358 hasConcept C42219234 @default.
• W2024697358 hasConcept C535046627 @default.
• W2024697358 hasConcept C55493867 @default.
• W2024697358 hasConcept C71924100 @default.
• W2024697358 hasConceptScore W2024697358C126322002 @default.
• W2024697358 hasConceptScore W2024697358C142724271 @default.
• W2024697358 hasConceptScore W2024697358C181199279 @default.
• W2024697358 hasConceptScore W2024697358C185592680 @default.
• W2024697358 hasConceptScore W2024697358C197934379 @default.
• W2024697358 hasConceptScore W2024697358C203092338 @default.
• W2024697358 hasConceptScore W2024697358C204787440 @default.
• W2024697358 hasConceptScore W2024697358C27081682 @default.
• W2024697358 hasConceptScore W2024697358C2776164576 @default.
• W2024697358 hasConceptScore W2024697358C2776467144 @default.
• W2024697358 hasConceptScore W2024697358C2778582115 @default.
• W2024697358 hasConceptScore W2024697358C2779689624 @default.
• W2024697358 hasConceptScore W2024697358C42219234 @default.
• W2024697358 hasConceptScore W2024697358C535046627 @default.

• next