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• W2024700660 abstract "Purpose: Avidin-coupled monoclonal antibody MX35 (avidin-MX35) and astatine-211–labeled, biotinylated, succinylated poly-l-lysine (211At-B-PLsuc) were administered in mice to assess potential efficacy as an intraperitoneal (i.p.) therapy for microscopic tumors. We aimed to establish a timeline for pretargeted radioimmunotherapy using these substances, and estimate the maximum tolerable activity. Methods:125I-avidin-MX35 and 211At-B-PLsuc were administered i.p. in nude mice. Tissue distributions were studied at various time points and mean absorbed doses were estimated from organ uptake of 211At-B-PLsuc. Studies of myelotoxicity were performed after administration of different activities of 211At-B-PLsuc. Results: We observed low blood content of both 125I-avidin-MX35 and 211At-B-PLsuc, indicating fast clearance. After sodium perchlorate blocking, the highest 211At uptake was found in kidneys. Red bone marrow (RBM) accumulated some 211At activity. Mean absorbed doses of special interest were 2.3 Gy/MBq for kidneys, 0.4 Gy/MBq for blood, and 0.9 Gy/MBq for RBM. An absorbed dose of 0.9 Gy to the RBM was found to be safe. These values suggested that RBM would be the key dose-limiting organ in the proposed pretargeting scheme, and that blood data alone was not sufficient for predicting its absorbed dose. Conclusions: To attain a favorable distribution of activity and avoid major toxicities, at least 1.0 MBq of 211At-B-PLsuc can be administered 24 hours after an i.p. injection of avidin-MX35. These results provide a basis for future i.p. therapy studies in mice of microscopic ovarian cancer." @default.
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• W2024700660 date "2011-12-01" @default.
• W2024700660 modified "2023-09-23" @default.
• W2024700660 title "In Vivo Distribution of Avidin-Conjugated MX35 and 211At-Labeled, Biotinylated Poly-l-Lysine for Pretargeted Intraperitoneal α-Radioimmunotherapy" @default.
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• W2024700660 doi "https://doi.org/10.1089/cbr.2011.1046" @default.
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