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- W2024701246 abstract "THE HE URINARY excretion of peptide bound hydroxyproline reflects the rate of bone collagen metabolism<sup>1-3</sup>being elevated in disorders affecting bone such as hyperthyroidism,<sup>1,3-5</sup>hyperparathyroidism,1,3,6 acromegaly,<sup>1,3</sup>Paget's disease of bone,<sup>1,3,5,7</sup>Marfan's syndrome,<sup>8</sup>Hurler's syndrome,<sup>9</sup>malabsorption states (with secondary osteomalacia,<sup>7</sup>and rheumatoid arthritis.<sup>10</sup>The immediate derivation of urinary hydroxyproline, whether from catabolism of mature bone<sup>2,8</sup>or from synthesis of soluble collagen fractions<sup>2,5,6</sup>or from both is disputed. Elevated hydroxyproline with normal skeletal radiographs has been reported in pregnancy and postpartum involution,<sup>11</sup>psoriasis (with and without arthritis),<sup>12,13</sup>thermal burns,<sup>14</sup>and mental deficiency states.<sup>15,16</sup> Since 1956, hydroxyproline excretion rates have been reported in 80 cases of malignancy with and without bone involvement.<sup>5,9,10,17-21</sup>The present communication reports the observations in 117 additional adult patients with malignant neoplastic disease. <h3>Methods</h3> Normal adults and adult patients with cancer in various primary sites and stages were studied. Whenever possible, patients were studied prior to" @default.
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- W2024701246 date "1966-12-01" @default.
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- W2024701246 title "Hydroxyproline Excretion in Malignant Neoplastic Disease" @default.
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- W2024701246 doi "https://doi.org/10.1001/archinte.1966.00290180041008" @default.
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