Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024703041> ?p ?o ?g. }
- W2024703041 endingPage "567" @default.
- W2024703041 startingPage "561" @default.
- W2024703041 abstract "Oxidized low density lipoprotein (LDL) may play an important role in the pathogenesis of atherosclerosis. Recent evidence strongly suggests that oxidized LDL is present in atherosclerotic lesions in vivo: 1) LDL isolated from human and rabbit lesions (but not from normal intima) resembles oxidized LDL in its physical, chemical and immunological properties; 2) Oxidized LDL and/or oxidation specific lipid-protein adducts can be demonstrated in human and rabbit lesions by immunocytochemical techniques; 3) Human and rabbit serum contains autoantibodies against oxidized LDL and oxidation specific lipid-protein adducts; 4) atherosclerotic lesions contain IgG that recognizes oxidized LDL and 5) antioxidant therapy slows the development of atherosclerotic lesions in rabbits. Atherosclerosis in human and rabbit arteries may be linked to macrophage-induced oxidative modification of LDL mediated by 15-lipoxygenase which leads to an enhanced uptake of LDL in macrophages by way of the scavenger receptor(s). The identification of LDL oxidation as one of the key events in the early pathogenesis of atherosclerosis offers an interesting possibility to reduce atherosclerosis by antioxidants, enzyme inhibitors and other compounds that protect LDL against oxidative damage and/or reduce the subsequent harmful effects of oxidized LDL on various cellular functions." @default.
- W2024703041 created "2016-06-24" @default.
- W2024703041 creator A5014220812 @default.
- W2024703041 date "1991-01-01" @default.
- W2024703041 modified "2023-10-17" @default.
- W2024703041 title "Macrophages and Oxidized Low Density Lipoproteins in the Pathogenesis of Atherosclerosis" @default.
- W2024703041 cites W1595210603 @default.
- W2024703041 cites W1604097175 @default.
- W2024703041 cites W18245585 @default.
- W2024703041 cites W19387050 @default.
- W2024703041 cites W1958895744 @default.
- W2024703041 cites W1968541049 @default.
- W2024703041 cites W1968567802 @default.
- W2024703041 cites W1968679020 @default.
- W2024703041 cites W1973816138 @default.
- W2024703041 cites W1974288109 @default.
- W2024703041 cites W1974790290 @default.
- W2024703041 cites W1977126756 @default.
- W2024703041 cites W1977778060 @default.
- W2024703041 cites W1978383066 @default.
- W2024703041 cites W1978470067 @default.
- W2024703041 cites W1980592834 @default.
- W2024703041 cites W1980809568 @default.
- W2024703041 cites W1991726504 @default.
- W2024703041 cites W2000239031 @default.
- W2024703041 cites W2000548860 @default.
- W2024703041 cites W2001720727 @default.
- W2024703041 cites W2004789344 @default.
- W2024703041 cites W2005115885 @default.
- W2024703041 cites W2005230846 @default.
- W2024703041 cites W2005910570 @default.
- W2024703041 cites W2006029962 @default.
- W2024703041 cites W2021140878 @default.
- W2024703041 cites W2021873664 @default.
- W2024703041 cites W2022439153 @default.
- W2024703041 cites W2026075546 @default.
- W2024703041 cites W2030720809 @default.
- W2024703041 cites W2036852690 @default.
- W2024703041 cites W2038484123 @default.
- W2024703041 cites W2040579726 @default.
- W2024703041 cites W2041142457 @default.
- W2024703041 cites W2041504897 @default.
- W2024703041 cites W2042667997 @default.
- W2024703041 cites W2046946523 @default.
- W2024703041 cites W2047075849 @default.
- W2024703041 cites W2053806341 @default.
- W2024703041 cites W2055111376 @default.
- W2024703041 cites W2058841561 @default.
- W2024703041 cites W2061755142 @default.
- W2024703041 cites W2064179373 @default.
- W2024703041 cites W2066100169 @default.
- W2024703041 cites W2081119605 @default.
- W2024703041 cites W2081304820 @default.
- W2024703041 cites W2081863011 @default.
- W2024703041 cites W2083217753 @default.
- W2024703041 cites W2085378323 @default.
- W2024703041 cites W2085600362 @default.
- W2024703041 cites W2104573407 @default.
- W2024703041 cites W2115909480 @default.
- W2024703041 cites W2154760942 @default.
- W2024703041 cites W2162458714 @default.
- W2024703041 cites W2165773709 @default.
- W2024703041 cites W2170583921 @default.
- W2024703041 cites W2183879979 @default.
- W2024703041 cites W2326202471 @default.
- W2024703041 cites W2896279173 @default.
- W2024703041 cites W4238714531 @default.
- W2024703041 cites W4240237349 @default.
- W2024703041 doi "https://doi.org/10.3109/07853899109150518" @default.
- W2024703041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1721825" @default.
- W2024703041 hasPublicationYear "1991" @default.
- W2024703041 type Work @default.
- W2024703041 sameAs 2024703041 @default.
- W2024703041 citedByCount "89" @default.
- W2024703041 countsByYear W20247030412012 @default.
- W2024703041 countsByYear W20247030412013 @default.
- W2024703041 countsByYear W20247030412015 @default.
- W2024703041 countsByYear W20247030412017 @default.
- W2024703041 countsByYear W20247030412018 @default.
- W2024703041 countsByYear W20247030412019 @default.
- W2024703041 countsByYear W20247030412022 @default.
- W2024703041 countsByYear W20247030412023 @default.
- W2024703041 crossrefType "journal-article" @default.
- W2024703041 hasAuthorship W2024703041A5014220812 @default.
- W2024703041 hasConcept C126322002 @default.
- W2024703041 hasConcept C134018914 @default.
- W2024703041 hasConcept C150903083 @default.
- W2024703041 hasConcept C159654299 @default.
- W2024703041 hasConcept C163764329 @default.
- W2024703041 hasConcept C185592680 @default.
- W2024703041 hasConcept C202751555 @default.
- W2024703041 hasConcept C203014093 @default.
- W2024703041 hasConcept C207001950 @default.
- W2024703041 hasConcept C2776151105 @default.
- W2024703041 hasConcept C2776393769 @default.
- W2024703041 hasConcept C2777895019 @default.
- W2024703041 hasConcept C2778004101 @default.
- W2024703041 hasConcept C2778163477 @default.