FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024704465> ?p ?o ?g. }

• W2024704465 endingPage "1072" @default.
• W2024704465 startingPage "1070" @default.
• W2024704465 abstract "In this issue of Cephalalgia Tuka and colleagues examine and compare levels of pituitary adenylate cyclaseactivating polypeptide-38 (PACAP-38) with calcitonin gene-related peptide (CGRP) in blood from the cubital vein of 87 migraineurs (ictal and interictal) and of 40 healthy controls. The authors report that both peptides are elevated in the peripheral circulation during migraine attacks as compared to their levels between attacks. There was no association with gender, age, attack frequency, allodynia, visual analogue scale score or migraine type (1). PACAP-38 was lower in interictal blood of the patients than in healthy controls. The reason behind this is not clear but we should realize that any analysis of peptides in the peripheral circulation reflects PACAP-38 levels that may come from the entire body, and therefore it is difficult to link it directly to the brain or to cranial structures. Since both PACAP-38 and CGRP are elevated during migraine attacks, the authors suggest a role in migraine. Another interesting finding is the observation of significant release of PACAP-38 during migraine attacks (i) in nonmenstrual migraine and (ii) in subjects without chronic back pain. The implication is so far not clear but opens the way for more research. In support of this study, the Copenhagen group has revealed that intravenous administration of PACAP-38 results in headache in healthy individuals and in migraine-like effects (after a mean of six hours) in migraine without aura patients (2). This group has in addition reported that PACAP-38 results in a related increase in the diameter of cranial arteries (2,3). They propose that PACAP-38 caused vasodilation, which resulted in the headache, providing support for the vascular theory of migraine (4). Because the closely related peptide vasoactive intestinal peptide (VIP) elicits the same degree of vasodilatation via the same type of receptors but lacks the migraine-inducing response (5), we are awaiting the head-to-head comparison study and an explanation of this interesting observation." @default.
• W2024704465 created "2016-06-24" @default.
• W2024704465 creator A5084413123 @default.
• W2024704465 date "2013-04-10" @default.
• W2024704465 modified "2023-09-23" @default.
• W2024704465 title "Role of VIP/PACAP in primary headaches" @default.
• W2024704465 cites W1977286827 @default.
• W2024704465 cites W1981423842 @default.
• W2024704465 cites W1990130323 @default.
• W2024704465 cites W1994330810 @default.
• W2024704465 cites W2000797422 @default.
• W2024704465 cites W2013033676 @default.
• W2024704465 cites W2014348068 @default.
• W2024704465 cites W2018978482 @default.
• W2024704465 cites W2030038644 @default.
• W2024704465 cites W2036679916 @default.
• W2024704465 cites W2039206911 @default.
• W2024704465 cites W2041847544 @default.
• W2024704465 cites W2042397716 @default.
• W2024704465 cites W2058095503 @default.
• W2024704465 cites W2069950730 @default.
• W2024704465 cites W2073742256 @default.
• W2024704465 cites W2080936371 @default.
• W2024704465 cites W2081968925 @default.
• W2024704465 cites W2083821823 @default.
• W2024704465 cites W2084884436 @default.
• W2024704465 cites W2086563745 @default.
• W2024704465 cites W2110874400 @default.
• W2024704465 cites W2113200425 @default.
• W2024704465 cites W2123640336 @default.
• W2024704465 cites W2156047574 @default.
• W2024704465 cites W2166206304 @default.
• W2024704465 doi "https://doi.org/10.1177/0333102413483929" @default.
• W2024704465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23575820" @default.
• W2024704465 hasPublicationYear "2013" @default.
• W2024704465 type Work @default.
• W2024704465 sameAs 2024704465 @default.
• W2024704465 citedByCount "15" @default.
• W2024704465 countsByYear W20247044652013 @default.
• W2024704465 countsByYear W20247044652014 @default.
• W2024704465 countsByYear W20247044652015 @default.
• W2024704465 countsByYear W20247044652016 @default.
• W2024704465 countsByYear W20247044652017 @default.
• W2024704465 countsByYear W20247044652018 @default.
• W2024704465 countsByYear W20247044652020 @default.
• W2024704465 countsByYear W20247044652023 @default.
• W2024704465 crossrefType "journal-article" @default.
• W2024704465 hasAuthorship W2024704465A5084413123 @default.
• W2024704465 hasBestOaLocation W20247044651 @default.
• W2024704465 hasConcept C118303440 @default.
• W2024704465 hasConcept C121332964 @default.
• W2024704465 hasConcept C126322002 @default.
• W2024704465 hasConcept C1276947 @default.
• W2024704465 hasConcept C141071460 @default.
• W2024704465 hasConcept C15744967 @default.
• W2024704465 hasConcept C169760540 @default.
• W2024704465 hasConcept C170493617 @default.
• W2024704465 hasConcept C2777977315 @default.
• W2024704465 hasConcept C2780966972 @default.
• W2024704465 hasConcept C3017995614 @default.
• W2024704465 hasConcept C71924100 @default.
• W2024704465 hasConcept C8330315 @default.
• W2024704465 hasConceptScore W2024704465C118303440 @default.
• W2024704465 hasConceptScore W2024704465C121332964 @default.
• W2024704465 hasConceptScore W2024704465C126322002 @default.
• W2024704465 hasConceptScore W2024704465C1276947 @default.
• W2024704465 hasConceptScore W2024704465C141071460 @default.
• W2024704465 hasConceptScore W2024704465C15744967 @default.
• W2024704465 hasConceptScore W2024704465C169760540 @default.
• W2024704465 hasConceptScore W2024704465C170493617 @default.
• W2024704465 hasConceptScore W2024704465C2777977315 @default.
• W2024704465 hasConceptScore W2024704465C2780966972 @default.
• W2024704465 hasConceptScore W2024704465C3017995614 @default.
• W2024704465 hasConceptScore W2024704465C71924100 @default.
• W2024704465 hasConceptScore W2024704465C8330315 @default.
• W2024704465 hasIssue "13" @default.
• W2024704465 hasLocation W20247044651 @default.
• W2024704465 hasLocation W20247044652 @default.
• W2024704465 hasOpenAccess W2024704465 @default.
• W2024704465 hasPrimaryLocation W20247044651 @default.
• W2024704465 hasRelatedWork W1966638871 @default.
• W2024704465 hasRelatedWork W1995680439 @default.
• W2024704465 hasRelatedWork W2003450342 @default.
• W2024704465 hasRelatedWork W2010519611 @default.
• W2024704465 hasRelatedWork W2016899150 @default.
• W2024704465 hasRelatedWork W2027568289 @default.
• W2024704465 hasRelatedWork W2030613578 @default.
• W2024704465 hasRelatedWork W2084109973 @default.
• W2024704465 hasRelatedWork W2554635175 @default.
• W2024704465 hasRelatedWork W2771967742 @default.
• W2024704465 hasVolume "33" @default.
• W2024704465 isParatext "false" @default.
• W2024704465 isRetracted "false" @default.
• W2024704465 magId "2024704465" @default.
• W2024704465 workType "article" @default.