Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024705100> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2024705100 abstract "Using the copper assisted halogen exchange the MAO-B inhibitor Ro 43-0463, N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide, was labelled with 123I as well as with 125I to allow in vitro and in vivo investigations including SPET with healthy volunteers. Ro 43-0463 is known to inhibit reversibly and specifically MAO-B, having an IC50 of 3 x 10(-8) Mol/L. The labeling in the presence of CuSO4 and ascorbic acid was optimised, varying time (30 to 105 min), precursor concentration (1-3.5 mg) and temperature (130-200 degrees C). The labeling yield ranged between 60 and 70%. Purification was achieved with Lichrosorb RP-18 (5 micron, 250 x 8 mm) and 1.5 mL/min 0.36 M H3PO4/EtOH 97/3 [0.01 M (NH4)2HPO4]. After neutralisation and sterile filtration the final activity concentration ranged between 18.5 and 37 MBq/mL. Biodistribution studies showed a brain to blood ratio greater than 1 within 1 h p.i. The main radiation burden calculated from these animal data is to alimentary and excretory organs and the ovaries. Autoradiography was performed using rat brain slices and 5 nM [125I]Ro 43-0463 in TRIS-buffer pH 7.4 for 90 min at 20 degrees C. Its radioactivity pattern corresponds to the known distribution of MAO-B in the rat brain. By displacement with L-deprneyl the highly specific binding of R0 43-0463 was proven in vitro. SPECT studies with normal volunteers corresponded with the pattern found in autoradiography." @default.
- W2024705100 created "2016-06-24" @default.
- W2024705100 creator A5037995427 @default.
- W2024705100 creator A5040680402 @default.
- W2024705100 creator A5044781501 @default.
- W2024705100 creator A5047526739 @default.
- W2024705100 creator A5068736965 @default.
- W2024705100 date "1995-10-01" @default.
- W2024705100 modified "2023-10-14" @default.
- W2024705100 title "123I-labeling and evaluation of Ro 43–0463, a spet tracer for MAO-B imaging" @default.
- W2024705100 cites W1567406210 @default.
- W2024705100 cites W1586462676 @default.
- W2024705100 cites W1977073009 @default.
- W2024705100 cites W1980691314 @default.
- W2024705100 cites W1987397108 @default.
- W2024705100 cites W2024260805 @default.
- W2024705100 cites W2026136779 @default.
- W2024705100 cites W2038603385 @default.
- W2024705100 cites W2042695207 @default.
- W2024705100 cites W2062852247 @default.
- W2024705100 cites W2075980813 @default.
- W2024705100 cites W2077052941 @default.
- W2024705100 cites W2109856572 @default.
- W2024705100 cites W2122107956 @default.
- W2024705100 cites W2142456895 @default.
- W2024705100 cites W2153777409 @default.
- W2024705100 cites W2254194967 @default.
- W2024705100 cites W2412461951 @default.
- W2024705100 cites W2606572887 @default.
- W2024705100 cites W40006496 @default.
- W2024705100 doi "https://doi.org/10.1016/0969-8051(95)00041-u" @default.
- W2024705100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8547891" @default.
- W2024705100 hasPublicationYear "1995" @default.
- W2024705100 type Work @default.
- W2024705100 sameAs 2024705100 @default.
- W2024705100 citedByCount "6" @default.
- W2024705100 crossrefType "journal-article" @default.
- W2024705100 hasAuthorship W2024705100A5037995427 @default.
- W2024705100 hasAuthorship W2024705100A5040680402 @default.
- W2024705100 hasAuthorship W2024705100A5044781501 @default.
- W2024705100 hasAuthorship W2024705100A5047526739 @default.
- W2024705100 hasAuthorship W2024705100A5068736965 @default.
- W2024705100 hasConcept C150903083 @default.
- W2024705100 hasConcept C177322064 @default.
- W2024705100 hasConcept C185592680 @default.
- W2024705100 hasConcept C202751555 @default.
- W2024705100 hasConcept C207001950 @default.
- W2024705100 hasConcept C2989005 @default.
- W2024705100 hasConcept C55493867 @default.
- W2024705100 hasConcept C71924100 @default.
- W2024705100 hasConcept C86803240 @default.
- W2024705100 hasConceptScore W2024705100C150903083 @default.
- W2024705100 hasConceptScore W2024705100C177322064 @default.
- W2024705100 hasConceptScore W2024705100C185592680 @default.
- W2024705100 hasConceptScore W2024705100C202751555 @default.
- W2024705100 hasConceptScore W2024705100C207001950 @default.
- W2024705100 hasConceptScore W2024705100C2989005 @default.
- W2024705100 hasConceptScore W2024705100C55493867 @default.
- W2024705100 hasConceptScore W2024705100C71924100 @default.
- W2024705100 hasConceptScore W2024705100C86803240 @default.
- W2024705100 hasLocation W20247051001 @default.
- W2024705100 hasLocation W20247051002 @default.
- W2024705100 hasOpenAccess W2024705100 @default.
- W2024705100 hasPrimaryLocation W20247051001 @default.
- W2024705100 hasRelatedWork W1566729005 @default.
- W2024705100 hasRelatedWork W2005835527 @default.
- W2024705100 hasRelatedWork W2116210813 @default.
- W2024705100 hasRelatedWork W2138350991 @default.
- W2024705100 hasRelatedWork W2386538333 @default.
- W2024705100 hasRelatedWork W2409285845 @default.
- W2024705100 hasRelatedWork W2433842723 @default.
- W2024705100 hasRelatedWork W2434195791 @default.
- W2024705100 hasRelatedWork W2788599012 @default.
- W2024705100 hasRelatedWork W3015376786 @default.
- W2024705100 isParatext "false" @default.
- W2024705100 isRetracted "false" @default.
- W2024705100 magId "2024705100" @default.
- W2024705100 workType "article" @default.