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- W2024705191 abstract "This study was undertaken to demonstrate the synthesis of glutathione (GSH) in Mercenaria mercenaria brown cells to test the hypothesis that failure to achieve 100% mortality with metal treatment is the result of high concentrations of GSH heterogeneously distributed in the brown cell population and to determine the effect of Cd2+, Cu2+, and Pb2+ on the GSH status in brown cells. The monochlorobimane (MCB) assay appeared to be selective for GSH in brown cells and a close relationship between the levels of GSH measured by MCB and a standard enzymatic method was found. The fluorescent GSH-bimane adduct, once formed within the cell, was not released from the cell. The technique was used to establish that GSH was synthesized in brown cells and was heterogeneously distributed in the brown cell population. Metal concentrations as high as 40 mM cadmium, 6.0 μM copper, or 20 mM lead did not deplete but caused decreases in brown cell GSH concentration that differed significantly (P < 0.05) from controls. The decrease caused by cadmium, copper, and lead was not in a dose dependent manner, whereas, the decrease caused by N-ethylmaleimide (NEM) was. It appears that the partial kill phenomenon associated with metal toxicity may be due to the heterogeneous distribution of GSH in the brown cell population." @default.
- W2024705191 created "2016-06-24" @default.
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- W2024705191 date "1997-02-01" @default.
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- W2024705191 title "Use of Monochlorobimane to Determine the In Vivo Effect of Cadmium, Copper and Lead on Glutathione Status in Mercenaria mercenaria Brown Cells" @default.
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- W2024705191 doi "https://doi.org/10.1016/s0742-8413(96)00162-4" @default.
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