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• W2024705269 abstract "No AccessJournal of UrologyInvestigative Urology1 Apr 2008Reduction of Oxidative Stress in Cultured Renal Tubular Cells and Preventive Effects on Renal Stone Formation by the Bioflavonoid Quercetinis companion ofUse of Sevelamer Hydrochloride as an Oxalate Binderis corrected byOxidative Stress In Cultured Renal Tubular Cells Hyoung Keun Park, Byong Chang Jeong, Mi-Kyung Sung, Mi-Young Park, Eun Young Choi, Bong Sub Kim, Hyeon H. Kim, and Jeong In Kim Hyoung Keun ParkHyoung Keun Park Department of Urology, College of Medicine, Dongguk University, Seoul, South Korea More articles by this author , Byong Chang JeongByong Chang Jeong Department of Urology, College of Medicine, Seoul National University, Seoul, South Korea More articles by this author , Mi-Kyung SungMi-Kyung Sung Department of Food and Nutrition, Sookmyung Women’s University, Seoul, South Korea More articles by this author , Mi-Young ParkMi-Young Park Department of Food and Nutrition, Sookmyung Women’s University, Seoul, South Korea More articles by this author , Eun Young ChoiEun Young Choi Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea More articles by this author , Bong Sub KimBong Sub Kim Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea More articles by this author , Hyeon H. KimHyeon H. Kim Department of Urology, College of Medicine, Seoul National University, Seoul, South Korea Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea More articles by this author , and Jeong In KimJeong In Kim Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Institute of Basic Sciences, Inje University, Gimhae, South Korea More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.11.039AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the effects of quercetin on renal tubular cell injury induced by oxalate and the inhibitory effects of quercetin on urinary crystal deposit formation in an animal model. Materials and Methods: MDCK cells (American Type Culture Collection, Manassas, Virginia) were incubated with different concentrations of oxalate with and without quercetin. MTT (Sigma®) assays for cell viability, malondialdehyde and catalase activity were measured to investigate the antioxidant effect of quercetin. Male Sprague-Dawley rats were divided into 3 groups. Group 1 was fed standard rat chow. Groups 2 and 3 rats were fed standard chow supplemented with 3% sodium oxalate for 4 weeks. For the first 8 days in 4 weeks each rat in groups 2 and 3 also received gentamicin intramuscularly. Additionally, group 3 rats were administered quercetin for 4 weeks. Rats were sacrificed after 4 weeks, after which 24-hour urine collections and kidney removal were performed. In the renal tissue malondialdehyde, superoxide dismutase and catalase activity was measured. Bisected kidneys were examined under microscopy to determine the number of crystals. Results: The viability of MDCK cells significantly decreased and malondialdehyde production increased in the presence of oxalate. However, co-exposure to quercetin inhibited the decrease in cell viability and inhibited the lipid peroxidation production induced by oxalate. In the animal study malondialdehyde production in group 3 significantly decreased compared to that in group 2. Catalase and superoxide dismutase activity was increased in group 3 compared to that in group 2. The number of crystals in kidneys in group 3 was decreased significantly compared to that in group 2. Conclusions: Quercetin has an inhibitory effect on urinary crystal deposit formation. References 1 : Oxalate ion and calcium oxalate crystal interactions with renal epithelial cells. In: Kidney Stones: Medical and Surgical Management. Edited by . Philadelphia: Lippincott-Raven1996: 129. chapt 43. Google Scholar 2 : Mechanisms of stone formation—an overview. Scan Electron Microsc1984; 3: 1419. 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Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byAssimos D (2018) Re: MitoTEMPO Prevents Oxalate Induced Injury in NRK-52E Cells via Inhibiting Mitochondrial Dysfunction and Modulating Oxidative StressJournal of Urology, VOL. 200, NO. 2, (239-241), Online publication date: 1-Aug-2018.Assimos D (2018) Re: Calcium Oxalate Induces Renal Injury through Calcium-Sensing ReceptorJournal of Urology, VOL. 197, NO. 5, (1297-1297), Online publication date: 1-May-2017.Xue Y, He D, Chen X, Li X, Zeng J and Wang X (2018) Shock Wave Induced Kidney Injury Promotes Calcium Oxalate DepositionJournal of Urology, VOL. 182, NO. 2, (762-765), Online publication date: 1-Aug-2009.Related articlesJournal of Urology19 Feb 2008Use of Sevelamer Hydrochloride as an Oxalate BinderJournal of Urology21 May 2008Oxidative Stress In Cultured Renal Tubular Cells Volume 179Issue 4April 2008Page: 1620-1626 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordskidney calculikidneySprague-DawleyantioxidantsratsquercetinMetricsAuthor Information Hyoung Keun Park Department of Urology, College of Medicine, Dongguk University, Seoul, South Korea More articles by this author Byong Chang Jeong Department of Urology, College of Medicine, Seoul National University, Seoul, South Korea More articles by this author Mi-Kyung Sung Department of Food and Nutrition, Sookmyung Women’s University, Seoul, South Korea More articles by this author Mi-Young Park Department of Food and Nutrition, Sookmyung Women’s University, Seoul, South Korea More articles by this author Eun Young Choi Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea More articles by this author Bong Sub Kim Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea More articles by this author Hyeon H. Kim Department of Urology, College of Medicine, Seoul National University, Seoul, South Korea Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea More articles by this author Jeong In Kim Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Institute of Basic Sciences, Inje University, Gimhae, South Korea More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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