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- W2024706535 abstract "An NMR model for the study of drug interactions with solid tumour is described. It is based on the use of packed cells in a simple medium. The system is capable of dealing with cellular biochemistry at a molecular level through experiments conducted in a homogeneous field by 1H spin-echo NMR spectroscopy. However, through a simple imaging technique, it is also possible to introduce a spatial element into the chemistry of the packed cells. The use of these complementary NMR methods are illustrated by the action of the cytotoxic agent doxorubicin on cellular glycolysis. A pattern of signals observed in a homogeneous field experiment following oxidative stress are duplicated in the imaging experiment to illustrate the toxins' ability to penetrate the model tumour." @default.
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- W2024706535 date "1990-01-01" @default.
- W2024706535 modified "2023-09-27" @default.
- W2024706535 title "An NMR compatible model for solid tumour" @default.
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- W2024706535 doi "https://doi.org/10.1016/0731-7085(90)80110-b" @default.
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