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- W2024707310 abstract "The free amino acids present in ethanolic extracts of homogenates of various tissues of the normal rat, and of rats treated with an LD99.9 dose of ammonium acetate preceded or not by protective doses of l-arginine. HCl, were determined by quantitative paper chromatography. The most striking observations made were (a) a very considerable increase of liver aspartic acid in animals treated with ammonia alone, and of aspartic acid, glutamic acid, and urea in the livers of animals treated with ammonia and protective arginine, some 15 min. after injection of the ammonia, with no great change in glutamine levels at any time; (b) moderate increases of glutamine in the muscle extract of animals given ammonia alone, and of glutamine and urea in extracts of this tissue in animals given both ammonia and protective arginine; and (c) considerable increases of glutamine in extracts of brain and of testis with no change in urea levels at any time. It is concluded that ammonia is dealt with in the liver by the Krebs-Henseleit-Ratner cycle, and in brain and testis through the synthesis of glutamine." @default.
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- W2024707310 title "Studies on the metabolism of amino acids and related compounds in vivo. VI. Free amino acid levels in the tissues of rats protected against ammonia toxicity" @default.
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- W2024707310 doi "https://doi.org/10.1016/0003-9861(57)90337-5" @default.
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