Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024708573> ?p ?o ?g. }
- W2024708573 endingPage "66" @default.
- W2024708573 startingPage "57" @default.
- W2024708573 abstract "The development of hippocampal neuronal sensitivities to the β-noradrenergic agent, isoproterenol, was examined in tissue from immature rats. The in vitro hippocampal slice preparation was used to assess intracellularly recorded responses from hippocampal neurons to pressure-pulse and bath application of noradrenergic drugs. Effects of the drug on individual hippocampal CA3 pyramidal neurons were compared across several stages of development, ranging from postnatal day 4–5 (P4–5) to maturity. Isoproterenol, pressure-pulse applied to CA3c pyramidal cells, produced a depolarization of membrane potential and an increase in cell input resistance in tissue as young as P7. Spike frequency adaptation (in trains of action potentials triggered by depolarizing pulses) was reduced, as were the slow after-hyperpolarizations following the spike trains. All agonist effects were blocked by timolol, a β-antagonist. Drug-induced changes in cell membrane and firing properties in immature tissue were qualitatively similar to β-receptor-mediated noradrenergic effects in adult tissue. These results indicate that the β-receptor-mediated component of the noradrenergic effect in rat hippocampus is physiologically functional by the seventh day of postnatal life; at earlier times (P4–5) these β-receptor-mediated noradrenergic actions are, at best, equivocal." @default.
- W2024708573 created "2016-06-24" @default.
- W2024708573 creator A5035366534 @default.
- W2024708573 creator A5039203405 @default.
- W2024708573 date "1992-05-01" @default.
- W2024708573 modified "2023-09-23" @default.
- W2024708573 title "Pyramidal neurons in immature rat hippocampus are sensitive to β-adrenergic agents" @default.
- W2024708573 cites W1494574304 @default.
- W2024708573 cites W1598537134 @default.
- W2024708573 cites W1658103071 @default.
- W2024708573 cites W1774425002 @default.
- W2024708573 cites W1963979034 @default.
- W2024708573 cites W1963992694 @default.
- W2024708573 cites W1966650187 @default.
- W2024708573 cites W1966977187 @default.
- W2024708573 cites W1971288350 @default.
- W2024708573 cites W1975258323 @default.
- W2024708573 cites W1976669574 @default.
- W2024708573 cites W1977542480 @default.
- W2024708573 cites W1980275914 @default.
- W2024708573 cites W1984001225 @default.
- W2024708573 cites W1988152811 @default.
- W2024708573 cites W1988192817 @default.
- W2024708573 cites W1994667935 @default.
- W2024708573 cites W1995176921 @default.
- W2024708573 cites W1997464685 @default.
- W2024708573 cites W1997481436 @default.
- W2024708573 cites W2000974824 @default.
- W2024708573 cites W2001492196 @default.
- W2024708573 cites W2001539070 @default.
- W2024708573 cites W2003104573 @default.
- W2024708573 cites W2003867734 @default.
- W2024708573 cites W2006402903 @default.
- W2024708573 cites W2008704583 @default.
- W2024708573 cites W2011119678 @default.
- W2024708573 cites W2014987595 @default.
- W2024708573 cites W2024260091 @default.
- W2024708573 cites W2029118604 @default.
- W2024708573 cites W2034481695 @default.
- W2024708573 cites W2036895913 @default.
- W2024708573 cites W2037650611 @default.
- W2024708573 cites W2045043687 @default.
- W2024708573 cites W2052788570 @default.
- W2024708573 cites W2054525776 @default.
- W2024708573 cites W2060299786 @default.
- W2024708573 cites W2064793866 @default.
- W2024708573 cites W2067899373 @default.
- W2024708573 cites W2068232954 @default.
- W2024708573 cites W2068793916 @default.
- W2024708573 cites W2072064154 @default.
- W2024708573 cites W2074322760 @default.
- W2024708573 cites W2075807545 @default.
- W2024708573 cites W2075998556 @default.
- W2024708573 cites W2076927394 @default.
- W2024708573 cites W2077821862 @default.
- W2024708573 cites W2079098497 @default.
- W2024708573 cites W2079133060 @default.
- W2024708573 cites W2083435654 @default.
- W2024708573 cites W2083528466 @default.
- W2024708573 cites W2087725006 @default.
- W2024708573 cites W2088727446 @default.
- W2024708573 cites W2090998238 @default.
- W2024708573 cites W2091288653 @default.
- W2024708573 cites W2092156835 @default.
- W2024708573 cites W2092622844 @default.
- W2024708573 cites W2093963631 @default.
- W2024708573 cites W2094257560 @default.
- W2024708573 cites W2094491913 @default.
- W2024708573 cites W2113449040 @default.
- W2024708573 cites W2127939929 @default.
- W2024708573 cites W2135430901 @default.
- W2024708573 cites W2147608198 @default.
- W2024708573 cites W2403704540 @default.
- W2024708573 cites W2430686689 @default.
- W2024708573 cites W4233773865 @default.
- W2024708573 cites W4319308273 @default.
- W2024708573 cites W719433 @default.
- W2024708573 doi "https://doi.org/10.1016/0165-3806(92)90025-r" @default.
- W2024708573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1638743" @default.
- W2024708573 hasPublicationYear "1992" @default.
- W2024708573 type Work @default.
- W2024708573 sameAs 2024708573 @default.
- W2024708573 citedByCount "4" @default.
- W2024708573 crossrefType "journal-article" @default.
- W2024708573 hasAuthorship W2024708573A5035366534 @default.
- W2024708573 hasAuthorship W2024708573A5039203405 @default.
- W2024708573 hasConcept C126322002 @default.
- W2024708573 hasConcept C134018914 @default.
- W2024708573 hasConcept C148762608 @default.
- W2024708573 hasConcept C169760540 @default.
- W2024708573 hasConcept C170493617 @default.
- W2024708573 hasConcept C2778437258 @default.
- W2024708573 hasConcept C2778514916 @default.
- W2024708573 hasConcept C2778938600 @default.
- W2024708573 hasConcept C2781161787 @default.
- W2024708573 hasConcept C40465926 @default.
- W2024708573 hasConcept C4141045 @default.
- W2024708573 hasConcept C513476851 @default.