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• W2024709377 abstract "A318 Aims: This study is to investigate the pharmacokinetics of MPA, MPAG after single and multiple oral administration of MMF; and to compare the pharmacokinetics parameters in Chinese kidney transplant patients with those in other countries. Methods: 12 Chinese patients (6 male and 6 female, mean age 36±7.1, mean body weight 56±10.3 kg), who received renal transplanta-tion in our hospital during Sept. 2002 to June 2003 were eligible for entry. After an overnight fast, patients participated in a single 1g dose of MMF pharmacokinetic study before renal transplantation. Then the patients received kidney transplantation and taken 1g MMF twice a day. On the 12th day post-operation, at 0.5, 1, 1.5, 2, 2.5, 4, 6, 8, 10, 12h after MMF administration, 4ml blood was drawn for deter-mination of drugs pharmacokinetics. Acetonitrile was added into plasma specimen for protein precipitation, then the concentration of MPA and MPAG was simultaneous measured by RP-HPLC using gradient elution. The concentration-time data were treated by using 3P97 phar-macokinetic software. Using Pared-Samples T test (Self-Contrast 9 with SPSS statistical software (a=0.05). Results and Discussions: (1) The pharmacokinetics of MPA, MPAG after single and multiple oral administration of MMF in Chinese patients with renal transplantation showed that the MPA plasma concentration-time profiles were fitted as a two compartment open model and the MPAG plasma concentration-time profiles were fitted as a single compartment open model with a linear kinetic absorption. (2) Compared with the literature reports in other countries, the main pharmacokinetic parameters of MPA and MPAG of our research have some difference as follow:FigureWhether the race difference would influence pharmacokinetic parameters of MPA and MPAG or not, it still needs further research. (3)The parent drug MMF was undetectable in plasma during oral administration, confirming the rapid conversion of MMF to MPA. In mean MPA concentration-time curve after single and multiple dose, a secondary peak occurred for MPA during 6∼10 h, attributed to enterohepatic recirculation. These results are similar to the literature reports in other countries. (4) There was significant variation of MPA plasma concentration-time data among subjects, in either single dose study or multiple dose study. It is noticed that the therapeutic plan (1g oral MMF, twice a day), which is adopted popularly in clinical therapy, doesn’t emphasize on the individual variation among patients. It is suggested that Therapeutic Drug Monitoring (TDM) should be applied in dosage optimisation. This Study is supported by the Grant from Shanghai Roche Pharmaceutics Ltd." @default.
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• W2024709377 date "2004-07-01" @default.
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• W2024709377 title "PHARMACOKINETICS OF MYCOPHENOLIC ACID AND ITS GLUCURONIDE AFTER A SINGLE AND MULTIPLE ORAL DOSE OF MYCOPHENOLATE MOFETIL IN CHINESE PATIENTS WITH RENAL TRANSPLANTATION" @default.
• W2024709377 doi "https://doi.org/10.1097/00007890-200407271-02044" @default.
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