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- W2024709571 abstract "We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25–100 mg/kg, p.o.), as well as the γ-amino-butyric acidA/benzodiazepine (GABAA/BZP) receptor agonist diazepam (1–3 mg/kg, i.p.), dose dependently increased the SI time, respectively. The GABAA receptor antagonist picrotoxin blocked the effects of TJ-24 and diazepam. TJ-24-induced SI behavior was significantly blocked by the GABAA/BZP receptor inverse agonist Ro 15-4513 and the GABAA/BZP receptor antagonist flumazenil. In addition, 5α-reductase inhibitor finasteride potently blocked the effect of TJ-24 without attenuating the basal level by itself. These findings suggest that TJ-24 shows the anxiolytic effect through the neurosteroid synthesis followed by GABAA/BDZ receptor stimulations." @default.
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- W2024709571 date "2001-09-01" @default.
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- W2024709571 title "Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice Possible mediation of neurosteroid synthesis" @default.
- W2024709571 doi "https://doi.org/10.1016/s0024-3205(01)01290-5" @default.
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