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• W2024716223 abstract "Platelet-activating factor (PAF) augments angiogenesis by promoting the synthesis of a variety of angiogenic factors, via the nuclear factor (NF)-κB activation. Recently, we reported that PAF upregulates MMP-9 expression in a NF-κB-dependent manner. In this study, we investigated the signaling pathway involved in PAF-induced MMP-9 expression in ECV304 cells. Our current data indicate that the Ca2+- or phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is necessary for PAF-induced MMP-9 expression. Furthermore, PAF-induced NF-κB activation was blocked by selective inhibitors of Ca2+, PI3K, or extracellular signal-regulated kinase (ERK). Our results suggest that PAF-induced MMP-9 expression, in a NF-κB-dependent manner, is regulated by Ca2+, PI3K and ERK signaling pathways." @default.
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• W2024716223 date "2005-11-02" @default.
• W2024716223 modified "2023-10-16" @default.
• W2024716223 title "Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca2+- or PI3K-dependent signaling pathway in a human vascular endothelial cell line" @default.
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• W2024716223 doi "https://doi.org/10.1016/j.febslet.2005.10.027" @default.
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