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• W2024720725 abstract "ObjectiveTo describe the first reported case of gestational carrier treatment to prevent severe early onset pre-eclampsia.DesignCase report.SettingA university-based reproductive endocrinology and infertility clinic and a tertiary care hospital.Patient(s)A 29-year-old woman and her husband with three consecutive pregnancies complicated by early onset severe pre-eclampsia causing fetal demises at 22 and 24 weeks gestation; a neonatal death at 25 weeks gestation; and life-threatening maternal hemolysis, elevated liver enzymes, and low platelets.Intervention(s)An IVF procedure in the patient using her husband’s sperm with the transfer of two embryos to a friend who offered to be a gestational carrier.Main Outcome Measure(s)Successful IVF cycle in the patient and uncomplicated pregnancy and delivery in the gestational carrier.Result(s)The gestational carrier achieved a pregnancy and progressed without complications to delivery of a healthy, 3.2-kg infant at 39 weeks gestation.Conclusion(s)The use of a gestational carrier deserves consideration as a treatment option in patients with poor reproductive histories because of early onset severe pre-eclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. This experience also suggests that development of pre-eclampsia may be in large part maternally rather than embryologically or paternally driven. To describe the first reported case of gestational carrier treatment to prevent severe early onset pre-eclampsia. Case report. A university-based reproductive endocrinology and infertility clinic and a tertiary care hospital. A 29-year-old woman and her husband with three consecutive pregnancies complicated by early onset severe pre-eclampsia causing fetal demises at 22 and 24 weeks gestation; a neonatal death at 25 weeks gestation; and life-threatening maternal hemolysis, elevated liver enzymes, and low platelets. An IVF procedure in the patient using her husband’s sperm with the transfer of two embryos to a friend who offered to be a gestational carrier. Successful IVF cycle in the patient and uncomplicated pregnancy and delivery in the gestational carrier. The gestational carrier achieved a pregnancy and progressed without complications to delivery of a healthy, 3.2-kg infant at 39 weeks gestation. The use of a gestational carrier deserves consideration as a treatment option in patients with poor reproductive histories because of early onset severe pre-eclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. This experience also suggests that development of pre-eclampsia may be in large part maternally rather than embryologically or paternally driven." @default.
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• W2024720725 date "2007-01-01" @default.
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• W2024720725 title "Use of a gestational carrier for a patient with recurrent adverse pregnancy outcomes from early onset severe pre-eclampsia" @default.
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• W2024720725 doi "https://doi.org/10.1016/j.fertnstert.2006.04.050" @default.
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