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- W2024721825 abstract "In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-kappaB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the individual ginsenosides tested, Rh2, Rh3 and compound K significantly inhibited LPS-induced iNOS and cytokine expressions. Therefore, the inhibition of microglial activation by ginseng saponins may a good potential therapeutic modality for neurodegenerative diseases." @default.
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- W2024721825 date "2009-04-01" @default.
- W2024721825 modified "2023-10-16" @default.
- W2024721825 title "Anti-inflammatory mechanism of ginseng saponins in activated microglia" @default.
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- W2024721825 doi "https://doi.org/10.1016/j.jneuroim.2009.01.020" @default.
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