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• W2024722044 abstract "Human recombinant interleukin-1 alpha (IL-1) stimulated the mouse osteoblast-like cell line, MC3T3-E1, to produce prostaglandin E2 (PGE2). This was inhibited by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) in a dose-dependent manner. The protein kinase A (PKA)-specific inhibitor, KT5720, also inhibited the IL-1-induced PGE2 production in MC3T3-E1 cells, as did staurosporine, a potent inhibitor of protein kinase C (PKC). The PKA activator, 8-bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP), weakly stimulated MC3T3-E1 cells to produce PGE2, as did the PKC activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). However, 8-Br-cAMP and TPA acted synergistically to induce PGE2 production equal to that of IL-1. These observations suggest that activation of both PKA and PKC are involved in IL-1-induced PGE2 production in MC3T3-E1 cells." @default.
• W2024722044 created "2016-06-24" @default.
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• W2024722044 date "1994-03-01" @default.
• W2024722044 modified "2023-09-27" @default.
• W2024722044 title "Involvement of protein kinase A and C in the production of interleukin-1α-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1" @default.
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• W2024722044 doi "https://doi.org/10.1016/0167-4889(94)90219-4" @default.
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