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- W2024722718 abstract "The four-carbon fatty acid, n-butyrate is an inhibitor of cell division in vitro, but surprisingly in vivo n-butyrate is a stimulator of the gastrointestinal cell growth. In order to find any explanation of this discrepancy, our experiments were carried out in rumen epithelial cell (REC) and rumen connective tissue cell (RCTC) cultures at different pH values after n-butyrate addition, and the rate of cellular DNA synthesis was measured. The D-glucose and Na-n-butyrate metabolism, further the Na+/H+ exchange of the cells were also determined at different pH values. It was established that the cell division inhibitory action of n-butyrate in the REC, but not in the RCTC is a pH-dependent process, and the changing metabolism and transport processes of REC at different pH values can contribute in abrogating of the inhibitory action of butyrate." @default.
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- W2024722718 date "2001-01-01" @default.
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- W2024722718 title "The pH-dependent inhibitory action of n-butyrate on gastrointestinal epithelial cell division" @default.
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- W2024722718 doi "https://doi.org/10.1016/s0963-9969(01)00075-8" @default.
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