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- W2024722910 abstract "Previous investigations aimed at determining the role of corticopetal cholinergic afferents in cognition have relied upon human psychopharmacological studies, neuropsychological analyses of Alzheimer's patients, or psychopharmacological manipulations and excitotoxic lesions in animals. Unfortunately, each approach has its limitations. The interpretation of neuropsychological data relies upon correlations of post-mortem assessments of cholinergic degeneration that may be quite temporally distant from the time of cognitive assessment. In contrast, the use of animals allows direct manipulations of the cholinergic system and the establishment of causal relationships between acetylcholine and cognitive function but is limited by the selectivity of the toxins and drugs available to manipulate the system. The recent introduction of immunotoxins to lesion cortical cholinergic pathways with greater selectivity has allowed the effective testing of these hypotheses of cholinergic functions in cognition. Previous neuropsychological, psychopharmacological and excitotoxic lesion data are reviewed and compared to results produced using the more selective immunotoxins to provide an update to the current hypotheses of the role of corticopetal cholinergic afferents in cognitive function. Additionally, the conceptual and methodological cost and benefits of the methods of infusion used to produce lesions with these immunotoxins is assessed." @default.
- W2024722910 created "2016-06-24" @default.
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- W2024722910 creator A5020886846 @default.
- W2024722910 creator A5060932935 @default.
- W2024722910 creator A5070590297 @default.
- W2024722910 date "2000-11-01" @default.
- W2024722910 modified "2023-10-17" @default.
- W2024722910 title "The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins" @default.
- W2024722910 cites W1516658808 @default.
- W2024722910 cites W1813932451 @default.
- W2024722910 cites W1854670164 @default.
- W2024722910 cites W1940310886 @default.
- W2024722910 cites W1964640629 @default.
- W2024722910 cites W1965153010 @default.
- W2024722910 cites W1972718612 @default.
- W2024722910 cites W1977041705 @default.
- W2024722910 cites W1981256555 @default.
- W2024722910 cites W1982064952 @default.
- W2024722910 cites W1986142700 @default.
- W2024722910 cites W1987089253 @default.
- W2024722910 cites W1990697121 @default.
- W2024722910 cites W1992121966 @default.
- W2024722910 cites W1993456206 @default.
- W2024722910 cites W1994781353 @default.
- W2024722910 cites W1996007763 @default.
- W2024722910 cites W2002377358 @default.
- W2024722910 cites W2003451739 @default.
- W2024722910 cites W2003625937 @default.
- W2024722910 cites W2004713321 @default.
- W2024722910 cites W2005859034 @default.
- W2024722910 cites W2007511567 @default.
- W2024722910 cites W2010120109 @default.
- W2024722910 cites W2013854477 @default.
- W2024722910 cites W2015721558 @default.
- W2024722910 cites W2018027230 @default.
- W2024722910 cites W2018434736 @default.
- W2024722910 cites W2021346798 @default.
- W2024722910 cites W2026405510 @default.
- W2024722910 cites W2027009747 @default.
- W2024722910 cites W2028039974 @default.
- W2024722910 cites W2039276784 @default.
- W2024722910 cites W2040720776 @default.
- W2024722910 cites W2044466219 @default.
- W2024722910 cites W2044976640 @default.
- W2024722910 cites W2045694402 @default.
- W2024722910 cites W2048181379 @default.
- W2024722910 cites W2050586239 @default.
- W2024722910 cites W2051328423 @default.
- W2024722910 cites W2052301423 @default.
- W2024722910 cites W2054283463 @default.
- W2024722910 cites W2056558547 @default.
- W2024722910 cites W2057936308 @default.
- W2024722910 cites W2059415755 @default.
- W2024722910 cites W2059492003 @default.
- W2024722910 cites W2059982452 @default.
- W2024722910 cites W2062837885 @default.
- W2024722910 cites W2063060972 @default.
- W2024722910 cites W2069541573 @default.
- W2024722910 cites W2071444583 @default.
- W2024722910 cites W2080071110 @default.
- W2024722910 cites W2081522004 @default.
- W2024722910 cites W2082423614 @default.
- W2024722910 cites W2089496209 @default.
- W2024722910 cites W2093374391 @default.
- W2024722910 cites W2094205706 @default.
- W2024722910 cites W2098649821 @default.
- W2024722910 cites W2109298255 @default.
- W2024722910 cites W2113460545 @default.
- W2024722910 cites W2115849571 @default.
- W2024722910 cites W2119912272 @default.
- W2024722910 cites W2125426704 @default.
- W2024722910 cites W2139856187 @default.
- W2024722910 cites W2144414884 @default.
- W2024722910 cites W2146073951 @default.
- W2024722910 cites W2147457356 @default.
- W2024722910 cites W2153547750 @default.
- W2024722910 cites W2153762687 @default.
- W2024722910 cites W2160578045 @default.
- W2024722910 cites W2162671157 @default.
- W2024722910 cites W2209078744 @default.
- W2024722910 cites W2232548624 @default.
- W2024722910 cites W2258879186 @default.
- W2024722910 cites W2468690938 @default.
- W2024722910 cites W3022893628 @default.
- W2024722910 cites W4232833871 @default.
- W2024722910 cites W4236605003 @default.
- W2024722910 cites W4237210664 @default.
- W2024722910 cites W4238481893 @default.
- W2024722910 cites W4240774702 @default.
- W2024722910 cites W4242567297 @default.
- W2024722910 cites W4243321718 @default.
- W2024722910 cites W4247603503 @default.
- W2024722910 cites W4256593289 @default.
- W2024722910 doi "https://doi.org/10.1016/s0166-4328(00)00262-x" @default.
- W2024722910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11000424" @default.
- W2024722910 hasPublicationYear "2000" @default.
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