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- W2024725429 endingPage "e1003554" @default.
- W2024725429 startingPage "e1003554" @default.
- W2024725429 abstract "Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-throughput omics techniques have generated vast amounts of genotypic and molecular phenotypic data. However, these data have not yet been fully explored to improve the effectiveness and efficiency of drug discovery, which continues along a one-drug-one-target-one-disease paradigm. As a partial consequence, both the cost to launch a new drug and the attrition rate are increasing. Systems pharmacology and pharmacogenomics are emerging to exploit the available data and potentially reverse this trend, but, as we argue here, more is needed. To understand the impact of genetic, epigenetic, and environmental factors on drug action, we must study the structural energetics and dynamics of molecular interactions in the context of the whole human genome and interactome. Such an approach requires an integrative modeling framework for drug action that leverages advances in data-driven statistical modeling and mechanism-based multiscale modeling and transforms heterogeneous data from GWAS, high-throughput sequencing, structural genomics, functional genomics, and chemical genomics into unified knowledge. This is not a small task, but, as reviewed here, progress is being made towards the final goal of personalized medicines for the treatment of complex diseases." @default.
- W2024725429 created "2016-06-24" @default.
- W2024725429 creator A5029040247 @default.
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- W2024725429 creator A5085425476 @default.
- W2024725429 date "2014-05-15" @default.
- W2024725429 modified "2023-10-17" @default.
- W2024725429 title "Towards Structural Systems Pharmacology to Study Complex Diseases and Personalized Medicine" @default.
- W2024725429 cites W105356118 @default.
- W2024725429 cites W1501203786 @default.
- W2024725429 cites W1515782956 @default.
- W2024725429 cites W1595889060 @default.
- W2024725429 cites W1599271175 @default.
- W2024725429 cites W1906704471 @default.
- W2024725429 cites W1963859554 @default.
- W2024725429 cites W1965379872 @default.
- W2024725429 cites W1966827022 @default.
- W2024725429 cites W1968522790 @default.
- W2024725429 cites W1970290111 @default.
- W2024725429 cites W1972923838 @default.
- W2024725429 cites W1974365898 @default.
- W2024725429 cites W1974421522 @default.
- W2024725429 cites W1974643328 @default.
- W2024725429 cites W1976196984 @default.
- W2024725429 cites W1976738153 @default.
- W2024725429 cites W1979601325 @default.
- W2024725429 cites W1979887720 @default.
- W2024725429 cites W1979954275 @default.
- W2024725429 cites W1980274652 @default.
- W2024725429 cites W1980669422 @default.
- W2024725429 cites W1980800453 @default.
- W2024725429 cites W1981509058 @default.
- W2024725429 cites W1982320452 @default.
- W2024725429 cites W1982389355 @default.
- W2024725429 cites W1982542571 @default.
- W2024725429 cites W1982874561 @default.
- W2024725429 cites W1983518163 @default.
- W2024725429 cites W1984014392 @default.
- W2024725429 cites W1984017257 @default.
- W2024725429 cites W1984084871 @default.
- W2024725429 cites W1984658396 @default.
- W2024725429 cites W1985549756 @default.
- W2024725429 cites W1985911638 @default.
- W2024725429 cites W1986087295 @default.
- W2024725429 cites W1988136571 @default.
- W2024725429 cites W1988234678 @default.
- W2024725429 cites W1988739180 @default.
- W2024725429 cites W1989004527 @default.
- W2024725429 cites W1989024286 @default.
- W2024725429 cites W1989061197 @default.
- W2024725429 cites W1990495809 @default.
- W2024725429 cites W1991004166 @default.
- W2024725429 cites W1992120716 @default.
- W2024725429 cites W1993795323 @default.
- W2024725429 cites W1994658365 @default.
- W2024725429 cites W1994663540 @default.
- W2024725429 cites W1996529795 @default.
- W2024725429 cites W1996588166 @default.
- W2024725429 cites W2000059965 @default.
- W2024725429 cites W2001977454 @default.
- W2024725429 cites W2002937040 @default.
- W2024725429 cites W2003324165 @default.
- W2024725429 cites W2003984225 @default.
- W2024725429 cites W2005072000 @default.
- W2024725429 cites W2006803138 @default.
- W2024725429 cites W2006932016 @default.
- W2024725429 cites W2010427019 @default.
- W2024725429 cites W2010700988 @default.
- W2024725429 cites W2011033953 @default.
- W2024725429 cites W2012627860 @default.
- W2024725429 cites W2013445415 @default.
- W2024725429 cites W2013726100 @default.
- W2024725429 cites W2015147525 @default.
- W2024725429 cites W2016408686 @default.
- W2024725429 cites W2019523557 @default.
- W2024725429 cites W2019543926 @default.
- W2024725429 cites W2019974881 @default.
- W2024725429 cites W2020423296 @default.
- W2024725429 cites W2021112221 @default.
- W2024725429 cites W2022659284 @default.
- W2024725429 cites W2023170820 @default.
- W2024725429 cites W2023386301 @default.
- W2024725429 cites W2023947478 @default.
- W2024725429 cites W2024027732 @default.
- W2024725429 cites W2024872256 @default.
- W2024725429 cites W2024985940 @default.
- W2024725429 cites W2028820256 @default.
- W2024725429 cites W2031094493 @default.
- W2024725429 cites W2031290814 @default.
- W2024725429 cites W2033342433 @default.
- W2024725429 cites W2038252445 @default.
- W2024725429 cites W2038561883 @default.
- W2024725429 cites W2039473152 @default.