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- W2024726072 abstract "A short series of 4-nitro-N-phenylbenzamides was synthesized and evaluated for anticonvulsant properties and neurotoxicity. In mice dosed intraperitoneally, three of the four 4-nitro-N-phenylbenzamides were efficient in the maximal electroshock-induced seizure (MES) test, especially N-(2,6-dimethylphenyl)-4-nitrobenzamide (ED50 value in the MES test = 31.8 μmol/kg, TD50 = 166.9 μmol/kg, protective index [PI] = 5.2) and N-(2-chloro-6-methylphenyl)-4-nitrobenzamide (ED50 value in the MES test = 90.3 μmol/kg, TD50 = 1.068 μmol/kg, PI = 11.8). The latter 4-nitro-N-phenylbenzamide was also found to be active against seizures induced by subcutaneous pentylenetetrazole (sc Ptz) and was selected for further evaluation in rats dosed orally. In these conditions, N-(2-chloro-6-methylphenyl)-4-nitrobenzamide was found to be, in the MES test, three times more active than phenytoin and 4-amino-N-(2,6-dimethylphenyl)benzamide, two potent anti-MES agents." @default.
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- W2024726072 date "1995-01-01" @default.
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- W2024726072 title "Synthesis and anticonvulsant activity of some 4-nitro-N-phenylbenzamides" @default.
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- W2024726072 doi "https://doi.org/10.1016/0223-5234(96)88254-7" @default.
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