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- W2024731301 abstract "In the olfactory bulb, expression of tyrosine hydroxylase (TH) in juxtaglomerular neurons is dependent on innervation by the olfactory nerve. The presence of the neuropeptide calcitonin gene-related peptide (CGRP) within the olfactory nerve has led to the hypothesis that CGRP is responsible for regulation of TH expression in the bulbar neurons. On the other hand, other investigators claim that olfactory receptors never produce CGRP and that functional contact with olfactory axons regulates production of TH by bulbar neurons. Two different experimental procedures were used to test whether either CGRP or contact with the olfactory nerve is essential for production of TH by bulbar neurons in vivo. The peptidergic innervation of the olfactory bulb was eliminated either by neonatal capsaicin treatment, or by stereotaxic, electrolytic lesions of the ophthalmic division of the trigeminal nerve. Both of the treatments leave the olfactory innervation of the bulb intact while eliminating the CGRP-immunoreactive fibers in the olfactory nerve and glomeruli. Subsequent immunocytochemistry reveals a normal complement of bulbar TH-immunoreactive juxtaglomerular neurons in the absence of peptidergic innervation. In order to test whether olfactory nerve input is necessary for expression of TH in vivo, the anlage of the olfactory bulb was removed from embryonic (E16) rat pups and transplanted into the anterior chamber. These ectopic olfactory bulbs, although devoid of olfactory nerve input, contain numerous TH-immunoreactive neurons. Thus olfactory nerve input is not necessary for expression of TH in bulbar neurons." @default.
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- W2024731301 date "1992-08-01" @default.
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- W2024731301 title "Expression of the dopaminergic phenotype in the olfactory bulb: Neither calcitonin gene-related peptide nor olfactory input is necessary" @default.
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- W2024731301 doi "https://doi.org/10.1016/0304-3940(92)90222-s" @default.
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