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- W2024732662 abstract "Abstract A low‐level (0.5%), but troublesome, aldehyde impurity in a pharmaceutical product was conveniently removed from an existing process stream by employing a reactive, polystyrene‐based sulfonylhydrazine resin. Selection of this resin resulted from screening a number of adsorbents and reactive resins using a high throughput LC–MS approach. The sulfonylhydrazine resin was able to quickly remove an impurity from an existing, highly concentrated, product stream in DMF at a level of 20 mg resin for each gram of product. The material obtained from such treatment showed a greatly improved impurity profile, with an 85% reduction in the level of the aldehyde impurity and without introduction of additional impurities. Keywords: Reactive resinScavenger resinSelective adsorbentsAdsorbent screeningLC‐MS screeningFlow injection analysis" @default.
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- W2024732662 date "2003-01-01" @default.
- W2024732662 modified "2023-09-26" @default.
- W2024732662 title "Selective Removal of a Pharmaceutical Process Impurity Using a Reactive Resin" @default.
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- W2024732662 doi "https://doi.org/10.1081/jlc-120021763" @default.
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