FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024732892> ?p ?o ?g. }

• W2024732892 endingPage "1921" @default.
• W2024732892 startingPage "1913" @default.
• W2024732892 abstract "Testicular torsion is a medical emergency that requires immediate diagnosis and treatment to avoid subsequent testicular injury and infertility. PPARs are a family of nuclear hormone receptors belonging to the steroid receptor superfamily. Three PPAR isotypes (alpha, beta/delta and gamma) encoded by separate genes and showing different tissue distribution patterns have been identified. PPARbeta/delta is expressed in testis and its role is largely unknown. We tested whether pharmacological activation of PPARbeta/delta might protect the testis from ischemia and reperfusion injury.Adult male Sprague-Dawley rats were subjected to 1-hour testicular ischemia, followed by 24 hours of reperfusion. Sham testicular ischemia-reperfusion rats served as controls. The animals were randomized to receive immediately after detorsion 1) L-165,041 (4 mg/kg intraperitoneally), a potent agonist of PPARbeta/delta, 2) GW9662 (Calbiochem(R)) (4 mg/kg intraperitoneally), an antagonist of PPAR, 3) L-165,041 (4 mg/kg intraperitoneally) plus GW9662 (4 mg/kg intraperitoneally) concomitantly or 4) vehicle (1 ml/kg 10% dimethyl sulfoxide/NaCl solution). We evaluated testicular extracellular signal regulated kinase, tumor necrosis factor-alpha and interleukin-6 by Western blot. We also investigated PPARbeta/delta activation by Western blot, mRNA expression and organ damage.Testicular ischemia-reperfusion injury caused a significant increase in extracellular signal regulated kinase, tumor necrosis factor-alpha and interleukin-6 expression in each testis. Furthermore, histological examination revealed marked damage. L-165,041 administration increased the PPARbeta/delta message and protein, inhibited extracellular signal regulated kinase, tumor necrosis factor-alpha and interleukin-6 expression, and decreased histological damage. Concomitant administration of GW9662 reversed the protection exerted by PPARbeta/delta agonist.These findings indicate that PPARbeta/delta agonists might be an attractive therapeutic candidate for managing testicular torsion." @default.
• W2024732892 created "2016-06-24" @default.
• W2024732892 creator A5002511221 @default.
• W2024732892 creator A5006216749 @default.
• W2024732892 creator A5010245193 @default.
• W2024732892 creator A5014523351 @default.
• W2024732892 creator A5026283915 @default.
• W2024732892 creator A5059353158 @default.
• W2024732892 creator A5066907401 @default.
• W2024732892 creator A5071954690 @default.
• W2024732892 creator A5079780570 @default.
• W2024732892 creator A5080680155 @default.
• W2024732892 creator A5085715177 @default.
• W2024732892 creator A5087584745 @default.
• W2024732892 date "2009-04-01" @default.
• W2024732892 modified "2023-10-18" @default.
• W2024732892 title "Peroxisome Proliferator Activated Receptor β/δ Activation Prevents Extracellular Regulated Kinase 1/2 Phosphorylation and Protects the Testis From Ischemia and Reperfusion Injury" @default.
• W2024732892 cites W1544670237 @default.
• W2024732892 cites W2017671227 @default.
• W2024732892 cites W2023459898 @default.
• W2024732892 cites W2037598347 @default.
• W2024732892 cites W2052931002 @default.
• W2024732892 cites W2064064067 @default.
• W2024732892 cites W2065569779 @default.
• W2024732892 cites W2078735261 @default.
• W2024732892 cites W2102877034 @default.
• W2024732892 cites W2103185024 @default.
• W2024732892 cites W2105035935 @default.
• W2024732892 cites W2109230097 @default.
• W2024732892 cites W2130963659 @default.
• W2024732892 cites W2156460632 @default.
• W2024732892 cites W2159153230 @default.
• W2024732892 cites W4252630654 @default.
• W2024732892 cites W4252969106 @default.
• W2024732892 doi "https://doi.org/10.1016/j.juro.2008.11.095" @default.
• W2024732892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19237170" @default.
• W2024732892 hasPublicationYear "2009" @default.
• W2024732892 type Work @default.
• W2024732892 sameAs 2024732892 @default.
• W2024732892 citedByCount "31" @default.
• W2024732892 countsByYear W20247328922012 @default.
• W2024732892 countsByYear W20247328922013 @default.
• W2024732892 countsByYear W20247328922014 @default.
• W2024732892 countsByYear W20247328922015 @default.
• W2024732892 countsByYear W20247328922018 @default.
• W2024732892 countsByYear W20247328922019 @default.
• W2024732892 countsByYear W20247328922021 @default.
• W2024732892 countsByYear W20247328922022 @default.
• W2024732892 countsByYear W20247328922023 @default.
• W2024732892 crossrefType "journal-article" @default.
• W2024732892 hasAuthorship W2024732892A5002511221 @default.
• W2024732892 hasAuthorship W2024732892A5006216749 @default.
• W2024732892 hasAuthorship W2024732892A5010245193 @default.
• W2024732892 hasAuthorship W2024732892A5014523351 @default.
• W2024732892 hasAuthorship W2024732892A5026283915 @default.
• W2024732892 hasAuthorship W2024732892A5059353158 @default.
• W2024732892 hasAuthorship W2024732892A5066907401 @default.
• W2024732892 hasAuthorship W2024732892A5071954690 @default.
• W2024732892 hasAuthorship W2024732892A5079780570 @default.
• W2024732892 hasAuthorship W2024732892A5080680155 @default.
• W2024732892 hasAuthorship W2024732892A5085715177 @default.
• W2024732892 hasAuthorship W2024732892A5087584745 @default.
• W2024732892 hasConcept C104317684 @default.
• W2024732892 hasConcept C126322002 @default.
• W2024732892 hasConcept C134018914 @default.
• W2024732892 hasConcept C16685009 @default.
• W2024732892 hasConcept C17991360 @default.
• W2024732892 hasConcept C2776415932 @default.
• W2024732892 hasConcept C2780114680 @default.
• W2024732892 hasConcept C28406088 @default.
• W2024732892 hasConcept C541997718 @default.
• W2024732892 hasConcept C55493867 @default.
• W2024732892 hasConcept C71924100 @default.
• W2024732892 hasConcept C86803240 @default.
• W2024732892 hasConcept C95444343 @default.
• W2024732892 hasConcept C98274493 @default.
• W2024732892 hasConceptScore W2024732892C104317684 @default.
• W2024732892 hasConceptScore W2024732892C126322002 @default.
• W2024732892 hasConceptScore W2024732892C134018914 @default.
• W2024732892 hasConceptScore W2024732892C16685009 @default.
• W2024732892 hasConceptScore W2024732892C17991360 @default.
• W2024732892 hasConceptScore W2024732892C2776415932 @default.
• W2024732892 hasConceptScore W2024732892C2780114680 @default.
• W2024732892 hasConceptScore W2024732892C28406088 @default.
• W2024732892 hasConceptScore W2024732892C541997718 @default.
• W2024732892 hasConceptScore W2024732892C55493867 @default.
• W2024732892 hasConceptScore W2024732892C71924100 @default.
• W2024732892 hasConceptScore W2024732892C86803240 @default.
• W2024732892 hasConceptScore W2024732892C95444343 @default.
• W2024732892 hasConceptScore W2024732892C98274493 @default.
• W2024732892 hasIssue "4" @default.
• W2024732892 hasLocation W20247328921 @default.
• W2024732892 hasLocation W20247328922 @default.
• W2024732892 hasOpenAccess W2024732892 @default.
• W2024732892 hasPrimaryLocation W20247328921 @default.
• W2024732892 hasRelatedWork W1977918131 @default.
• W2024732892 hasRelatedWork W1990717759 @default.
• W2024732892 hasRelatedWork W2357995311 @default.

• next