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- W2024740073 abstract "Eluates were prepared from 27 cadaver kidney transplants removed because of rejection or obtained at autopsy. They were shown by immunoelectrophoresis and immunodiffusion to contain immunoglobulins and trace amounts of other plasma proteins including in many eluates an unidentified β globulin. Eleven eluates demonstrated a complement-dependent lymphocytotoxic activity and a MLC (mixed lymphocyte culture) inhibiting effect. Twelve eluates had a MLC blocking effect but were not cytotoxic and four eluates were inactive in both assays. No clear-cut correlation could be established between the presence of cytotoxic or blocking activity of the eluates and the time of rejection of the transplants or their histology. The presence of lymphocytotoxins in the eluates seemed to be dependant on the degree of HL-A incompatibility of the graft. The MLC blocking effect demonstrated by almost all eluates, had no correlation with the HL-A types of stimulating or responding cells. (One eluate was shown to be able to block the response of autologous lymphocytes to PHA, PWM, Candida albicans, and PPD.) In addition the MLC inhibiting activity of this eluate was removed by lymphocytes bearing the incompatible HL-A antigens of the transplant, and also, by the patient's own lymphocytes. This suggests that the blocking factor has an affinity for autologous as well as allogenic lymphocytes and may contain soluble antigen-antibody complexes. Lymphocytotoxic and/or blocking factors appear to be produced by most recipients of kidney grafts." @default.
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- W2024740073 date "1975-11-01" @default.
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- W2024740073 title "Immunological studies on eluates from human kidney grafts" @default.
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- W2024740073 doi "https://doi.org/10.1016/0090-1229(75)90089-6" @default.
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