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• W2024742908 abstract "<h3>BACKGROUND AND AIMS</h3> Matrix metalloproteinases (MMPs) are implicated in the tissue destruction associated with inflammatory diseases. Proctocolectomy with ileo-anal pouch (IAP) anastomosis is associated with pouchitis, particularly in patients with ulcerative colitis (UC). The aim of this study was to quantify MMP-1 and MMP-2 in inflamed and uninflamed pouches of patients with UC compared with those with active UC. IAP patients with familial adenomatous polyposis (FAP) served as controls. <h3>METHODS</h3> Biopsies were taken from 33 patients with IAP (UC, n=25; FAP, n=8) and from 10 UC patients. MMP-1 and MMP-2 were quantified using sandwich enzyme linked immunosorbent assays. In addition, northern and western blotting and in situ hybridisation experiments were performed. <h3>RESULTS</h3> In pouchitis (n=11), MMP-1 and MMP-2 concentrations were increased compared with uninflamed pouches of patients with UC (n=14) or FAP (n=8) (MMP-1 17.7 ng/mg protein <i>v</i> 7.8 (UC)<i>v</i> 7.6 (FAP), p⩽0.05; MMP-2 16.4<i>v </i>9.5 (UC) <i>v</i> 6.3 (FAP), p⩽0.05). Western and northern blots revealed increased MMP-1 and MMP-2 protein and transcript concentrations in inflamed pouches. Mesenchymal cells were identified as major producers of MMP-1 and MMP-2 in pouchitis. A similar increase in MMPs was observed in tissues of patients with active UC. <h3>CONCLUSIONS</h3> Our results support the hypothesis that MMPs are involved in mucosal destruction and crypt hyperplasia, as seen in pouchitis." @default.
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• W2024742908 date "2000-09-01" @default.
• W2024742908 modified "2023-09-30" @default.
• W2024742908 title "Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and ulcerative colitis" @default.
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• W2024742908 doi "https://doi.org/10.1136/gut.47.3.415" @default.
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