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- W2024743479 abstract "In order to determine the effect of cyanosis on platelet survival, experimental cyanosis was produced in dogs by anastomosing the left atrial appendage to the main pulmonary artery. The six cyanotic animals used in this study had arterial O2 saturations of 71%-85% and elevated hematocrits. By one month following surgery, the 51chromium-labeled autologous platelet half-life (PHL) decreased 15%-60% from preoperative values: two cyanotic dogs had progressive reduction of PHL at two and three months. Mo reduction in PHL occured in three sham operated control animals. Survival of platelets exchanged between cyanotic and control animals was determined. Platelets from cyanotic dogs studied in control animals had a 69%-87% shorter survival than the autologous PHL of the control animals, indicating an abnormality intrinsic to the platelet produced in the cyanotic dog. Normal platelets from control animals transfused into cyanotic dogs had the identical reduced survival of autologous platelets in that cyanotic animal, suggesting that some determinant of transfused platelet survival is extrinsic to the platelet. Three months after shunt closure in two dogs, the reduced PHL has persisted." @default.
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- W2024743479 date "1977-04-01" @default.
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- W2024743479 title "EFFECT OF EXPERIMENTAL CYANOSIS ON PLATELET SURVIVAL" @default.
- W2024743479 doi "https://doi.org/10.1203/00006450-197704000-00196" @default.
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