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- W2024750830 abstract "Abstract The many pharmacological and biochemical effects of caffeine may be explained in part by its inhibitory action in vivo and in vitro upon enzymes which metabolize purines. We have demonstrated that in Crithidia fasciculata this methylxanthine (as well as theophylline) is a rather weak competitive inhibitor of adenine aminohydrolase, ribonucleoside hydrolase, hypoxanthine and guanine phosphoribosyltransferases. Caffeine does not interfere with purine base transport in Crithidia, however in leucocytes purine uptake is reduced. While the methylxanthines are weak purine enzyme inhibitors, the large number of enzymes affected accounts for their physiological importance in these cells." @default.
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- W2024750830 date "1979-11-01" @default.
- W2024750830 modified "2023-09-25" @default.
- W2024750830 title "Caffeine: Its action on purine metabolizing enzymes" @default.
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- W2024750830 doi "https://doi.org/10.1016/0006-291x(79)90611-9" @default.
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