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- W2024751370 abstract "Three analogs (cpc-His-pyr, cpc-His(τMe)-pyr, cpc-Thi-pyr) of the thyrotropin releasing hormone, TRH (pGlu-His-Pro-NH2), have been synthesized and studied for TRH antagonistic activity in monkeys and in vitro, using isolated rat pituitaries. cpc-Thi-pyr inhibits the TRH induced release of TSH in vitro, cpc-His-pyr has inhibitory activity only in some experiments, while cpc-His(τMe)-pyr has none. Both cpc-Thi-pyr and cpc-His(τMe)-pyr appear to have slight agonistic activity. The TRH induced release of prolactin in monkeys could not be inhibited at dosages 1000-fold that of TRH." @default.
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- W2024751370 date "1975-10-01" @default.
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- W2024751370 title "Thyrotropin and prolactin inhibitory studies by compounds related to the thyrotropin releasing hormone" @default.
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- W2024751370 doi "https://doi.org/10.1016/0006-291x(75)90515-x" @default.
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