Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024752083> ?p ?o ?g. }
- W2024752083 endingPage "2435" @default.
- W2024752083 startingPage "2425" @default.
- W2024752083 abstract "Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that regulates cellular redox potential. In this study, we demonstrate that macrophage G6PD plays an important role in the modulation of proinflammatory responses and oxidative stress. The G6PD levels in macrophages in the adipose tissue of obese animals were elevated, and G6PD mRNA levels positively correlated with those of proinflammatory genes. Lipopolysaccharide (LPS) and free fatty acids, which initiate proinflammatory signals, stimulated macrophage G6PD. Overexpression of macrophage G6PD potentiated the expression of proinflammatory and pro-oxidative genes responsible for the aggravation of insulin sensitivity in adipocytes. In contrast, when macrophage G6PD was inhibited or suppressed via chemical inhibitors or small interfering RNA (siRNA), respectively, basal and LPS-induced proinflammatory gene expression was attenuated. Furthermore, macrophage G6PD increased activation of the p38 mitogen-activated protein kinase (MAPK) and NF-κB pathways, which may lead to a vicious cycle of oxidative stress and proinflammatory cascade. Together, these data suggest that an abnormal increase of G6PD in macrophages promotes oxidative stress and inflammatory responses in the adipose tissue of obese animals." @default.
- W2024752083 created "2016-06-24" @default.
- W2024752083 creator A5015139582 @default.
- W2024752083 creator A5043952560 @default.
- W2024752083 creator A5045088400 @default.
- W2024752083 creator A5053173795 @default.
- W2024752083 creator A5057094394 @default.
- W2024752083 creator A5072093385 @default.
- W2024752083 creator A5080563770 @default.
- W2024752083 creator A5085948818 @default.
- W2024752083 creator A5086677025 @default.
- W2024752083 creator A5087029570 @default.
- W2024752083 date "2013-06-01" @default.
- W2024752083 modified "2023-10-16" @default.
- W2024752083 title "Macrophage Glucose-6-Phosphate Dehydrogenase Stimulates Proinflammatory Responses with Oxidative Stress" @default.
- W2024752083 cites W1568529372 @default.
- W2024752083 cites W1587892340 @default.
- W2024752083 cites W1600472471 @default.
- W2024752083 cites W1811191752 @default.
- W2024752083 cites W1965089100 @default.
- W2024752083 cites W1967996072 @default.
- W2024752083 cites W1974033843 @default.
- W2024752083 cites W1978045299 @default.
- W2024752083 cites W1987641475 @default.
- W2024752083 cites W1992462947 @default.
- W2024752083 cites W1999732094 @default.
- W2024752083 cites W2000178052 @default.
- W2024752083 cites W2001743136 @default.
- W2024752083 cites W2002893295 @default.
- W2024752083 cites W2010151178 @default.
- W2024752083 cites W2010594655 @default.
- W2024752083 cites W2014867833 @default.
- W2024752083 cites W2016302829 @default.
- W2024752083 cites W2017814607 @default.
- W2024752083 cites W2018822649 @default.
- W2024752083 cites W2020685166 @default.
- W2024752083 cites W2025034297 @default.
- W2024752083 cites W2026259579 @default.
- W2024752083 cites W2027734621 @default.
- W2024752083 cites W2036451354 @default.
- W2024752083 cites W2038961236 @default.
- W2024752083 cites W2044635516 @default.
- W2024752083 cites W2047563937 @default.
- W2024752083 cites W2059571803 @default.
- W2024752083 cites W2060588008 @default.
- W2024752083 cites W2065873565 @default.
- W2024752083 cites W2065891531 @default.
- W2024752083 cites W2066389046 @default.
- W2024752083 cites W2071963896 @default.
- W2024752083 cites W2073882423 @default.
- W2024752083 cites W2077003625 @default.
- W2024752083 cites W2084947298 @default.
- W2024752083 cites W2085047409 @default.
- W2024752083 cites W2098616484 @default.
- W2024752083 cites W2100566062 @default.
- W2024752083 cites W2101328621 @default.
- W2024752083 cites W2102619095 @default.
- W2024752083 cites W2105448220 @default.
- W2024752083 cites W2108036042 @default.
- W2024752083 cites W2109662937 @default.
- W2024752083 cites W2111768081 @default.
- W2024752083 cites W2117022390 @default.
- W2024752083 cites W2129316761 @default.
- W2024752083 cites W2137174491 @default.
- W2024752083 cites W2138863798 @default.
- W2024752083 cites W2140244778 @default.
- W2024752083 cites W2152377123 @default.
- W2024752083 cites W2159199000 @default.
- W2024752083 cites W2165202791 @default.
- W2024752083 cites W2165604976 @default.
- W2024752083 cites W2166031628 @default.
- W2024752083 cites W4232981971 @default.
- W2024752083 cites W4250725029 @default.
- W2024752083 doi "https://doi.org/10.1128/mcb.01260-12" @default.
- W2024752083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3700093" @default.
- W2024752083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23572562" @default.
- W2024752083 hasPublicationYear "2013" @default.
- W2024752083 type Work @default.
- W2024752083 sameAs 2024752083 @default.
- W2024752083 citedByCount "87" @default.
- W2024752083 countsByYear W20247520832013 @default.
- W2024752083 countsByYear W20247520832014 @default.
- W2024752083 countsByYear W20247520832015 @default.
- W2024752083 countsByYear W20247520832016 @default.
- W2024752083 countsByYear W20247520832017 @default.
- W2024752083 countsByYear W20247520832018 @default.
- W2024752083 countsByYear W20247520832019 @default.
- W2024752083 countsByYear W20247520832020 @default.
- W2024752083 countsByYear W20247520832021 @default.
- W2024752083 countsByYear W20247520832022 @default.
- W2024752083 countsByYear W20247520832023 @default.
- W2024752083 crossrefType "journal-article" @default.
- W2024752083 hasAuthorship W2024752083A5015139582 @default.
- W2024752083 hasAuthorship W2024752083A5043952560 @default.
- W2024752083 hasAuthorship W2024752083A5045088400 @default.
- W2024752083 hasAuthorship W2024752083A5053173795 @default.
- W2024752083 hasAuthorship W2024752083A5057094394 @default.
- W2024752083 hasAuthorship W2024752083A5072093385 @default.