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- W2024754671 abstract "Two selective procedures are compared in an effort to isolate variants of mouse L cells containing structural gene mutations. Among the resulting variant cloned cell lines are found two types of alterations in the enzyme hypoxanthine phosphoribosyl transferase (EC 2.4.2.8) ( 1 ): enzyme with altered kinetic constants causing in vivo and in vitro resistance to 8-azaguanine; and ( 2 ) enzyme with altered heat sensitivity in vitro . These results support the view that tissue culture cell variants can arise from structural gene mutations." @default.
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- W2024754671 title "Altered Enzymes in Drug-Resistant Variants of Mammalian Tissue Culture Cells" @default.
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- W2024754671 doi "https://doi.org/10.1073/pnas.70.11.3145" @default.
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